What Is Myristoyl Hexapeptide-4?
Myristoyl Hexapeptide-4 is a lipopeptide created when myristic acid, a fatty acid commonly sourced from coconut oil or nutmeg, is chemically linked to Hexapeptide-4, a chain of six amino acids. The fatty acid portion helps the peptide move through the skin’s surface, while the peptide portion delivers its conditioning action. Peptide technology started gaining attention in the late 1990s as brands looked for gentler ways to promote a smoother, more resilient complexion; adding a lipid tail like myristic acid soon followed as a way to boost skin affinity. Today the ingredient is produced in controlled lab settings through solid-phase peptide synthesis, after which the myristic acid is attached and the finished material is purified and stabilized for cosmetic use. You are most likely to see Myristoyl Hexapeptide-4 in leave-on products such as anti-aging serums, eye creams, lightweight moisturizers, sheet masks and targeted treatment ampoules that aim to improve overall skin feel and appearance.
Myristoyl Hexapeptide-4’s Cosmetic Benefits/Uses
In cosmetic formulas Myristoyl Hexapeptide-4 is valued for the way it conditions the skin and supports a healthier looking complexion.
As a skin-conditioning agent it helps smooth the surface, improve softness and maintain moisture, which can give the skin a supple, refreshed look over time.
Who Can Use Myristoyl Hexapeptide-4
Thanks to its lightweight texture and gentle nature Myristoyl Hexapeptide-4 suits most skin types including dry, normal, combination and oily skins. Those with sensitive or reactive skin usually tolerate it well because the peptide is non-acidic and does not exfoliate. People with very acne-prone skin should check the full ingredient list of the finished product, as richer bases or heavy oils that surround the peptide in a formula might feel too occlusive even though the peptide itself is not considered pore clogging.
The ingredient is made in a lab from plant-derived myristic acid and a synthetic chain of amino acids so it is typically suitable for vegans and vegetarians. Brands that certify their supply chain as animal-free will usually highlight this on the label.
No specific concerns have been raised about topical use during pregnancy or while breastfeeding. This is not medical advice and anyone who is pregnant or nursing should ask a doctor before adding new skincare products just to be safe.
Myristoyl Hexapeptide-4 does not increase photosensitivity so daytime use is fine. Of course broad-spectrum sunscreen remains an everyday staple for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects and reactions to topical Myristoyl Hexapeptide-4 can vary from person to person. The points below list potential issues that could occur yet they are unlikely to be the typical user experience when the ingredient is formulated and used correctly.
- Mild redness or warmth at the application site
- Temporary itching or tingling as the product settles
- Localized irritation in people with a known sensitivity to fatty acids
- Allergic contact dermatitis in rare cases
- Breakout flare-up if the finished product contains comedogenic companions
If any of these reactions appear stop using the product and consult a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 1 / 5. Myristoyl Hexapeptide-4 on its own is a small peptide with a single myristic acid tail, so it is far less occlusive than whole plant oils or waxes that usually score higher. Its molecular size and partial water solubility help it sit lightly on the skin rather than forming a thick film that blocks pores. This makes it generally fine for people who are prone to acne or breakouts, provided the overall formula around it is also low in pore-clogging ingredients. Keep in mind that perceived congestion often comes from the richer emollients or silicones paired with the peptide, not the peptide itself.
Summary
Myristoyl Hexapeptide-4 is a lab-crafted lipopeptide that conditions skin by combining a fatty acid for penetration support with a six-amino-acid chain that signals smoother, softer texture. It is most often slipped into serums, eye creams and lightweight moisturizers where brands want a touch of peptide tech without heaviness. While not as famous as big-name collagen boosters like Matrixyl, it has earned a quiet following among formulators looking for gentle options that play well with many skin types.
Topical use is considered very safe, with low irritation potential and no known photosensitivity issues. Adverse reactions are rare, but as with any new skincare ingredient it is smart to do a small patch test before committing to full-face use, especially if you have sensitive or reactive skin.