What Is Myristoyl Pentapeptide-11?
Myristoyl Pentapeptide-11 is a lab made molecule created by attaching myristic acid, a fatty acid often sourced from coconut or palm kernel oil, to a short chain of five amino acids known as Pentapeptide-11. By combining a lipid and a peptide, chemists give the peptide better affinity for skin, helping it penetrate the skin’s surface where it can support a smoother feel.
Peptides began attracting attention in skin care during the early 2000s when researchers showed that certain amino acid chains could signal the skin to look and act younger. To improve stability and delivery, formulators started linking peptides to fatty acids like myristic acid. Myristoyl Pentapeptide-11 grew out of this wave of innovation and has been included in cosmetic products for more than a decade.
The ingredient is made through a controlled reaction in which myristic acid is activated then bonded to the N-terminus of Pentapeptide-11. The resulting compound is purified, dried, and delivered as a fine powder or pre-dissolved liquid for ease of use in manufacturing.
You will most often find Myristoyl Pentapeptide-11 in anti-aging serums, eye creams, sheet masks, moisturizers and leave-on treatments aimed at improving skin texture and suppleness.
Myristoyl Pentapeptide-11’s Cosmetic Benefits/Uses
This ingredient contributes to formulas by acting as a skin conditioning agent, meaning it helps the skin feel softer smoother and more resilient.
Who Can Use Myristoyl Pentapeptide-11
Because it is lightweight and non greasy, Myristoyl Pentapeptide-11 tends to suit all major skin types including dry, normal, combination and oily. People with sensitive skin usually tolerate it well since the molecule is gentle and fragrance free, though anyone with a known peptide allergy should proceed cautiously.
The ingredient is produced synthetically from plant sourced myristic acid and a lab made amino acid chain, so it is considered suitable for both vegans and vegetarians. Brands that certify cruelty free status also commonly use it because no animal testing is required for its manufacture.
Current research has not flagged any special concerns for pregnant or breastfeeding women. Still, safety data for this group is limited, and personal circumstances differ, so this information is not medical advice. Expectant or nursing mothers should show the product to their doctor before adding it to a routine.
Myristoyl Pentapeptide-11 does not increase photosensitivity, meaning it will not make skin more prone to sunburn. It also plays well with most other skincare actives, including vitamin C and niacinamide, making it easy to layer within a routine.
Potential Side Effects/Adverse Reactions
Reactions to topical Myristoyl Pentapeptide-11 vary from person to person. The points below outline potential issues that could occur, but they are uncommon when the ingredient is used at standard cosmetic levels and formulated correctly.
- Mild redness or irritation, especially on very reactive skin
- Temporary stinging when applied to broken or freshly exfoliated skin
- Allergic contact dermatitis in individuals sensitive to peptides or fatty acids
- Isolated cases of small pimples in people who are highly prone to clogged pores
If any of these effects occur, discontinue use and consult a healthcare professional to determine the best course of action.
Comedogenic Rating
Rating: 1 / 5 – Myristoyl Pentapeptide-11 is used at very low percentages and is water soluble once paired with suitable solvents, so it does not leave an occlusive film that traps oil or debris. While the myristic acid portion on its own can be pore clogging, coupling it to a peptide dramatically lowers that risk, and most finished formulas featuring this ingredient feel weightless. In practical terms it is considered safe for skin that is prone to acne or breakouts, though the overall formula and personal tolerance always matter.
As with any single raw material, the final comedogenic potential depends on the other ingredients in the product and individual skin chemistry, so results can vary slightly from person to person.
Summary
Myristoyl Pentapeptide-11 is a lab crafted combo of a fatty acid and a five unit peptide that conditions skin, helping it feel smoother, softer and more elastic. The myristic acid tail helps the peptide slip into the outer layers of skin while the amino acid chain supports a firmer feel, giving this ingredient a niche yet valued spot in anti aging serums and eye creams.
Though not as famous as retinol or vitamin C, it enjoys steady popularity among formulators who want a gentle peptide option that layers well with other actives and fits into vegan and cruelty free claims.
Overall safety data are favorable, and adverse reactions are rare when products are used as directed. Still, skin can react unpredictably so performing a small patch test with any new product that contains Myristoyl Pentapeptide-11 is always a smart move.