What Is Myristoyl Pentapeptide-15?
Myristoyl Pentapeptide-15 is a lipopeptide formed when myristic acid, a fatty acid commonly sourced from coconut oil, nutmeg and palm kernel oil, is chemically linked to Pentapeptide-15, a chain of five amino acids. Combining a lipid tail with a short peptide lets the molecule mingle with the skin’s natural oils while delivering the peptide where it is needed.
The cosmetic world has been experimenting with peptides since the early 2000s, looking for gentler ways to support a youthful look. Attaching a fatty acid such as myristic acid was a next step because it can help a peptide slip through the skin’s outer barrier. As formulators sought alternatives to well-known lipopeptides like palmitoyl pentapeptide-4, Myristoyl Pentapeptide-15 emerged as a newer option.
In the lab the peptide is created through solid-phase synthesis, where each amino acid is added one at a time. After the five-unit chain is complete, the myristic acid is coupled to one end, then the finished compound is purified and dried into a powder ready for creams or serums.
You will usually find Myristoyl Pentapeptide-15 in leave-on products designed to smooth and hydrate, such as lightweight serums, night creams, eye treatments, sheet masks and other anti-aging formulas. Its small size and lipid anchor make it popular in concentrated booster drops too.
Myristoyl Pentapeptide-15’s Cosmetic Benefits/Uses
In skincare formulas Myristoyl Pentapeptide-15 serves one main purpose: skin conditioning. By helping the surface feel softer and look more even it supports a healthier appearance overall.
Who Can Use Myristoyl Pentapeptide-15
Because it is lightweight and non-oily, Myristoyl Pentapeptide-15 is generally suitable for dry, normal, combination and even oily skin types. Its conditioning action supports moisture without leaving a heavy film, which makes it a pleasant choice for breakout-prone or mature skin as well. Extremely sensitive or highly reactive skin may still prefer to start with lower concentrations since any peptide can sometimes trigger a reaction in delicate complexions.
The ingredient is produced through lab synthesis using plant-derived myristic acid and amino acids, with no animal by-products involved. That means it aligns with vegan and vegetarian preferences when sourced from reputable suppliers.
Current research shows no known issues for pregnant or breastfeeding users when Myristoyl Pentapeptide-15 is applied topically, but this is not medical advice. Anyone who is expecting or nursing should review any new skincare item with their healthcare provider to be sure it fits their personal circumstances.
Unlike exfoliating acids or retinoids, this peptide does not make skin more sensitive to sunlight, so there is no added photosensitivity concern. Normal daily sun protection is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects from topical Myristoyl Pentapeptide-15 can vary between individuals. The points below list potential reactions, though most people will not experience them when the ingredient is used correctly in a well-formulated product.
- Mild redness or flushing
- Temporary stinging or tingling right after application
- Itchiness or a feeling of warmth in the treated area
- Localized swelling or puffiness in very sensitive skin
- Contact dermatitis or an allergic rash in rare cases
If any persistent irritation or unexpected reaction occurs, discontinue use and consult a healthcare professional or dermatologist for guidance.
Comedogenic Rating
Rating: 1 out of 5. Although the molecule contains myristic acid, which on its own can rank higher on the comedogenic scale, Myristoyl Pentapeptide-15 is used in very small amounts and the fatty acid is bound to a peptide that alters its behavior on skin. The ingredient is lightweight, absorbs quickly and does not leave a greasy residue, so it is unlikely to block pores. Most people prone to acne or breakouts can use it without added concern.
Formulation style matters; if the peptide sits inside a heavier cream packed with occlusive oils, the finished product could still feel clogging. Always consider the full ingredient list, not just the peptide itself, when choosing a product.
Summary
Myristoyl Pentapeptide-15 is a lab-crafted lipopeptide that conditions skin by helping the surface feel smoother and look more even. The myristic acid tail lets the five-amino-acid chain penetrate the outer layer more readily, where it can support a healthier moisture balance.
It is a niche ingredient, seen mostly in specialty serums, eye treatments and booster drops rather than mass-market moisturizers, but its presence is slowly growing as brands look for fresh peptide options.
Safety data so far show it is well tolerated with low risk of irritation or comedogenicity. As with any new skincare ingredient, patch testing is a smart step before full-face use to ensure individual compatibility.