What Is Myristoyl Sh-Oligopeptide-106 Sp?
Myristoyl Sh-Oligopeptide-106 Sp is a hybrid molecule created by linking myristic acid, a fatty acid naturally present in coconut oil and nutmeg, with Sh-Oligopeptide-106 Sp, a lab-crafted chain of amino acids modeled after the skin’s own signaling peptides. Scientists began experimenting with fatty-acylated peptides in the early 2000s when they discovered that adding a lipid tail helped water-loving peptides slip through the skin’s protective barrier more easily. Production starts with standard solid-phase peptide synthesis, after which the finished peptide is reacted with purified myristic acid to form a stable amide bond. The result is a small, skin-friendly molecule that is easier for topical formulas to deliver where it is needed. You are most likely to find Myristoyl Sh-Oligopeptide-106 Sp in anti-aging serums, concentrated eye creams, sheet masks, overnight treatments and rich moisturizers that target firmness and smoothness.
Myristoyl Sh-Oligopeptide-106 Sp’s Cosmetic Benefits/Uses
This ingredient is valued for one primary function in cosmetics.
Skin conditioning: By combining a peptide that can signal skin cells with a fatty acid that improves penetration, Myristoyl Sh-Oligopeptide-106 Sp helps skin feel softer, look more supple and maintain a healthy moisture balance. Regular use can support a smoother texture and a fresher, more resilient appearance.
Who Can Use Myristoyl Sh-Oligopeptide-106 Sp
Because it is a lightweight peptide linked to a gentle fatty acid Myristoyl Sh-Oligopeptide-106 Sp works for most skin types. Dry and mature skin can benefit from its conditioning boost while normal and combination skin enjoy the extra softness without feeling greasy. Oily and acne-prone types usually tolerate it well since the molecule is small and non-occlusive yet those extremely prone to breakouts may still prefer to patch test a finished formula to be sure.
The ingredient is made in a lab from myristic acid that is often sourced from plant oils and a synthetic peptide so it can be suitable for vegans and vegetarians when the brand confirms plant-based sourcing and no animal testing.
No data point to risks for pregnant or breastfeeding women when the ingredient is used topically at the tiny levels found in cosmetics. This is not medical advice and anyone who is pregnant or nursing should show the product to a healthcare professional for personal guidance.
Myristoyl Sh-Oligopeptide-106 Sp does not make skin more sensitive to sunlight. Normal daily sunscreen habits are still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects and reactions to topical Myristoyl Sh-Oligopeptide-106 Sp can differ from person to person. The points below cover potential issues yet most people will not notice any problems when the ingredient is used in a well-formulated product.
- Mild redness or warmth – a small number of users may feel temporary flushing as skin adjusts
- Itching or tingling – sensitive skin might react to the peptide portion causing a brief prickly feel
- Minor breakouts – very oily or congestion-prone skin could see extra blemishes if the overall formula is too rich
- Contact dermatitis – rare allergy to the peptide or other ingredients in the product may lead to rash or swelling
If any lasting irritation or discomfort occurs stop using the product and seek advice from a medical professional.
Comedogenic Rating
Rating: 1/5. Although the molecule carries a myristic acid tail, the acid is locked to a small peptide which changes how it behaves on skin. The compound is lightweight, absorbs quickly and does not create a heavy film that typically contributes to clogged pores. Most people prone to acne or frequent breakouts can use it without noticing extra congestion. If the finished product also contains rich butters or waxes, the overall pore-clogging potential may be higher so looking at the full formula is important.
Summary
Myristoyl Sh-Oligopeptide-106 Sp is a fatty-acylated peptide that conditions skin by pairing a penetration-boosting myristic acid tail with a signaling oligopeptide. This combo helps skin hold moisture, feel smoother and look more resilient.
The ingredient is still a niche player compared with staples like retinol or hyaluronic acid yet its gentle profile and stability are winning it a spot in more targeted serums, eye treatments and overnight creams.
Available safety data show a low chance of irritation or photosensitivity at cosmetic use levels, but it is always smart to patch test any new product containing this ingredient before full-face application.