What Is Myristoyl Sh-Oligopeptide-107 Sp?
Myristoyl Sh-Oligopeptide-107 Sp is a lab-made peptide that joins a short chain of skin-friendly amino acids (known as sh-Oligopeptide-107 Sp) with myristic acid, a fatty acid found in nut oils and some animal fats. The pairing helps the peptide blend well with the skin’s natural oils, making it easier for formulas to deliver its benefits. Peptide research took off in the late 1990s as brands searched for gentler alternatives to retinoids. Scientists discovered that linking peptides to fatty acids improved stability and absorption, which led to ingredients like Myristoyl Sh-Oligopeptide-107 Sp making their way into premium skin care around the mid-2000s.
Production starts with fermenting plant sugars to create the base peptide. This peptide is then reacted with purified myristic acid in a controlled setting. The result is a lipo-peptide that combines the signaling power of peptides with the smoothing feel of a light oil. Because it is fully synthetic every batch is consistent and free from animal by-products.
You will usually spot Myristoyl Sh-Oligopeptide-107 Sp in moisturizers, anti-aging serums, sheet masks, eye creams and targeted firming treatments where brands want a silky finish without heaviness.
Myristoyl Sh-Oligopeptide-107 Sp’s Cosmetic Benefits/Uses
This ingredient is prized for one standout job in skin care.
As a skin-conditioning agent Myristoyl Sh-Oligopeptide-107 Sp helps skin feel softer and smoother while supporting a healthy moisture barrier. The peptide portion can encourage a more even texture, and the fatty acid tail gives formulas a lightweight velvety slip that enhances spreadability and overall user experience.
Who Can Use Myristoyl Sh-Oligopeptide-107 Sp
Myristoyl Sh-Oligopeptide-107 Sp is generally suitable for normal, dry, combination and mature skin thanks to its lightweight conditioning feel. Oily and acne-prone skin types can usually use it too because the myristic acid portion is present in very small amounts that rarely feel greasy, though those who are extremely sebum-sensitive may prefer to patch test first. Sensitive skin users often tolerate the peptide well since it is fragrance free and non-exfoliating.
The ingredient is completely synthetic and does not rely on animal sources, so it fits vegan and vegetarian lifestyles.
No research has flagged Myristoyl Sh-Oligopeptide-107 Sp as unsafe for pregnancy or breastfeeding when used topically. This is not medical advice and anyone who is pregnant or nursing should run all skincare choices past a qualified healthcare professional to be extra sure.
The molecule is not known to cause photosensitivity, so daytime use alongside sunscreen is perfectly acceptable. It also plays nicely with most other common skincare actives such as niacinamide, vitamin C and retinoids.
Potential Side Effects/Adverse Reactions
Side effects from topical Myristoyl Sh-Oligopeptide-107 Sp can vary from person to person. The list below covers potential reactions only and most users will not experience them when the ingredient is used correctly in a well-formulated product.
- Transient redness or mild stinging in very sensitive skin
- Localized irritation if applied to broken or compromised skin
- Allergic contact dermatitis in the rare case of peptide sensitivity
- Minor clogged pores in individuals extremely prone to comedones
- Interaction-related irritation when layered immediately with strong exfoliating acids
If any adverse reaction develops discontinue use immediately and consult a healthcare professional or dermatologist for guidance.
Comedogenic Rating
Rating: 1 out of 5
While free myristic acid can rank as high as 3 or 4, in this molecule the fatty acid is chemically bound to a small peptide and used at low levels, which greatly reduces its pore clogging potential. The lipo-peptide format spreads thinly and absorbs quickly without leaving a heavy residue, so it is very unlikely to build up inside pores.
Overall this ingredient is considered suitable for acne-prone or breakout-prone skin in most cases.
Formulas that pair Myristoyl Sh-Oligopeptide-107 Sp with rich butters or waxes could shift the final product’s pore-clogging risk upward, so check the entire ingredient list if you are highly sensitive to congestion.
Summary
Myristoyl Sh-Oligopeptide-107 Sp is a lab-engineered lipo-peptide that conditions skin, supports a smoother texture and lends products a silky slip. The peptide side can signal skin to feel firmer while the myristic acid tail boosts absorption and leaves a light moisturizing film.
It ranks as a niche yet growing ingredient, most often found in mid to high-end serums, eye creams and sheet masks rather than in everyday drugstore staples.
Current data shows it to be safe for topical use with a very low irritation and comedogenic profile, making it friendly to most skin types including sensitive and acne-prone. As with any new skincare ingredient it is smart to try a patch test first to make sure your skin agrees with it.