What Is Myristoyl Tetrapeptide-13?
Myristoyl Tetrapeptide-13 is a lab crafted molecule formed when myristic acid, a naturally occurring fatty acid found in coconut and nut oils, is linked to a short chain of four amino acids called Tetrapeptide-13. By joining the fatty acid to the peptide chemists create a small yet stable compound that can slip more easily through the skin’s outer layers.
Peptides began gaining attention in skincare in the early 2000s when researchers discovered their ability to send helpful signals to the skin. To boost those signals formulators started attaching fatty acids like myristic acid, giving rise to lipidated peptides such as Myristoyl Tetrapeptide-13. The fatty tail improves both penetration and compatibility with the skin’s natural oils making the ingredient attractive for modern cosmetic lines.
Production starts with solid-phase peptide synthesis where the four amino acids are built one by one on a resin. After the sequence is complete myristic acid is chemically linked to the peptide’s end forming the final compound. The material is then purified, dried and delivered as a fine powder that easily dissolves into cosmetic bases.
You will most often find Myristoyl Tetrapeptide-13 in anti aging serums, firming moisturizers, eye creams, sheet masks and targeted neck or décolletage treatments where brands want a lightweight ingredient that can smooth and condition the skin without heaviness.
Myristoyl Tetrapeptide-13’s Cosmetic Benefits/Uses
In cosmetic formulas Myristoyl Tetrapeptide-13 serves one main purpose.
Skin conditioning: The peptide helps keep the skin feeling soft, supple and hydrated. By supporting the skin’s natural proteins and reinforcing its surface lipids it can improve overall texture diminish the appearance of fine lines and leave the complexion looking healthier and more refreshed.
Who Can Use Myristoyl Tetrapeptide-13
Because it is lightweight and non greasy Myristoyl Tetrapeptide-13 tends to agree with most skin types including oily, combination, normal and dry skin. Its gentle nature also makes it a good option for people with sensitive or reactive skin provided they are not allergic to any other ingredients in the finished product. There are no known reasons for acne prone users to avoid it as the molecule itself does not clog pores or feed acne causing bacteria.
The peptide is produced through laboratory synthesis so no animal derived materials are required. Myristic acid used in cosmetic manufacturing is almost always sourced from coconut or palm kernels which means products using Myristoyl Tetrapeptide-13 are generally suitable for vegans and vegetarians. Always check the full ingredient list and brand statements to confirm a formula aligns with personal ethics.
Current data does not indicate any special risks for women who are pregnant or breastfeeding when the ingredient is used in a typical topical concentration. That said long term studies in these groups are limited. This is not medical advice and pregnant or nursing individuals should run any skincare they use past a qualified healthcare provider to stay on the safe side.
Myristoyl Tetrapeptide-13 is not known to cause photosensitivity so it will not make the skin more prone to sunburn. Normal daytime sun protection habits should still be followed. The ingredient layers well with common actives such as niacinamide or hyaluronic acid and can be used morning or night.
Potential Side Effects/Adverse Reactions
Side effects and reactions to topical Myristoyl Tetrapeptide-13 vary from person to person. The following is a list of potential issues and most users will not experience any of them when the ingredient is formulated and used correctly.
- Mild redness or flushing particularly in very sensitive skin
- Temporary itching or tingling at the application site
- Localized rash or hives in individuals with a peptide or preservative allergy
- Contact dermatitis if combined with irritants in the overall formula
- Unintended enhanced penetration of strong actives which may amplify their irritation potential
If any negative reaction occurs stop using the product immediately and seek guidance from a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 1/5
Myristoyl Tetrapeptide-13 is built around a small peptide that is inherently non pore clogging and a single myristic acid chain that adds slip without creating a heavy occlusive film. In typical use levels of less than 2 percent the molecule disperses well in water based or light emulsions so it is unlikely to build up inside follicles.
With such a low comedogenic score this ingredient is generally considered suitable for people who are prone to acne or breakouts. As always the overall formula and accompanying ingredients will influence the final pore clogging potential.
Because it is a specialty active used in small amounts its impact on an entire product’s comedogenicity is minimal compared with richer oils or waxes that dominate the base.
Summary
Myristoyl Tetrapeptide-13 is a lab made peptide linked to myristic acid that conditions skin by supporting surface proteins reinforcing the lipid barrier and improving softness and hydration. The fatty tail lets the peptide slip through the outer skin layers helping deliver those benefits where they are most useful.
While not as famous as retinol or vitamin C this peptide has carved out a spot in anti aging serums, eye creams and sheet masks and its presence is gradually growing as brands look for gentle alternatives to more aggressive actives.
Current research and consumer feedback suggest it is safe for most skin types with a very low risk of irritation or clogged pores when used as directed. Even so anyone trying a new product that contains Myristoyl Tetrapeptide-13 should perform a quick patch test on a small area first to confirm personal tolerance.