What Is Myristoyl Tetrapeptide-34?
Myristoyl Tetrapeptide-34 is a lab made peptide created by linking a chain of four amino acids (a tetrapeptide) to myristic acid, a fatty acid that naturally occurs in coconut oil, palm kernel oil and nutmeg. The fatty acid tail acts like a delivery vehicle, helping the small peptide slip through the skin’s outer layer so it can do its job more efficiently.
Peptide technology began gaining attention in cosmetics in the late 1990s when researchers discovered that short chains of amino acids could signal skin cells to behave in a more youthful way. Myristoyl Tetrapeptide-34 is one of the newer members of this family, appearing in commercial formulas over the past decade as brands looked for gentler alternatives to more aggressive anti-aging ingredients.
Production starts with solid-phase peptide synthesis, a step-by-step method that links amino acids in a precise order. Once the tetrapeptide chain is complete, chemists attach it to myristic acid to increase its oil affinity and skin penetration. The finished ingredient is then purified, tested for stability and added to cosmetic bases at low concentrations.
You are most likely to find Myristoyl Tetrapeptide-34 in lightweight anti-aging serums, eye creams, all-over facial moisturizers, sheet masks, makeup-skin care hybrids and after-sun treatments that promise to brighten the look of skin while improving firmness and hydration.
Myristoyl Tetrapeptide-34’s Cosmetic Benefits/Uses
This ingredient is prized for one main role in skin care.
Skin conditioning: By supporting healthy cell communication Myristoyl Tetrapeptide-34 helps skin hold on to moisture, smooths rough texture and can encourage a more even, radiant tone. Regular use may make fine lines look softer and leave the surface feeling supple and refreshed.
Who Can Use Myristoyl Tetrapeptide-34
Most skin types can enjoy formulas featuring Myristoyl Tetrapeptide-34. Its lightweight character makes it comfortable for dry, normal, combination and even oily skin, while its gentle nature generally agrees with sensitive skin. Those with very oil-rich or acne-prone complexions may want to keep an eye on how their skin responds because the myristic acid tail, though present in a tiny amount, could feel slightly heavier than a purely water-based peptide.
The ingredient is made entirely in the lab without animal by-products so it is suitable for both vegans and vegetarians. Anyone following a cruelty-free lifestyle should still check the finished product’s overall policy on animal testing.
There is no evidence that topical Myristoyl Tetrapeptide-34 poses a specific risk to women who are pregnant or breastfeeding. That said this is not medical advice and expectant or nursing mothers should run any skin care product past a qualified health professional just to be safe.
Unlike acids and retinoids this peptide does not cause photosensitivity. You can use it morning or night although daily sunscreen is always smart for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to any cosmetic ingredient can vary from person to person. The effects listed below are possible but not likely if the formula has been made correctly and is used as directed.
- Mild redness or irritation The most common complaint when sensitivity occurs especially on very reactive skin
- Itchiness or stinging Usually short-lived and often linked to other actives or preservatives in the same product
- Allergic contact dermatitis A rare outcome that would show up as persistent rash or swelling
- Breakouts or clogged pores Uncommon but may happen on skin that already struggles with high oil flow
If you notice any of these issues stop using the product and consult a dermatologist or healthcare provider for guidance.
Comedogenic Rating
Rating: 1 out of 5
While myristic acid on its own can clog pores in higher amounts, Myristoyl Tetrapeptide-34 is used at very low levels and the fatty acid is only a small part of the overall molecule. The peptide portion is water loving, keeping the ingredient light and unlikely to build up inside pores. For most people, even those who break out easily, it should not trigger acne.
If you already struggle with very oily skin or find that products with richer fatty acids tend to block your pores, keep an eye on how your skin reacts but problems are rare.
Summary
Myristoyl Tetrapeptide-34 is mainly a skin-conditioning peptide that helps skin hold moisture, smooth texture and brighten tone by sending healthy signals to skin cells. The attached myristic acid acts like a shuttle, guiding the peptide through the skin’s surface so it can work where it is needed.
It is a niche ingredient, seen most often in mid- to high-end serums and eye creams rather than in everyday drugstore products, but its gentle profile is gaining quiet popularity among formulators who want milder anti-aging options.
Current research and consumer experience show it is a low-risk ingredient with only isolated reports of irritation or breakouts. Still, every skin is unique so it is smart to patch test any new product containing Myristoyl Tetrapeptide-34 before adding it to your routine.