What Is Myristoyl Tetrapeptide-46?
Myristoyl Tetrapeptide-46 is a lab-crafted molecule made when myristoyl chloride, a fatty acid derivative, reacts with a short chain of four amino acids known as Tetrapeptide-46. The fatty acid tail helps the peptide blend with the skin’s natural oils while the peptide part is designed to signal skin cells to behave in a healthier way. Peptide technology gained attention in the early 2000s as brands searched for gentler alternatives to harsh anti-aging actives; formulators soon discovered that attaching a fatty acid like myristic acid could improve peptide stability and delivery, giving rise to ingredients such as Myristoyl Tetrapeptide-46.
Manufacturing starts with synthesizing the tetrapeptide in a sterile environment, one amino acid at a time, using solid-phase peptide synthesis. The finished peptide is then reacted with myristoyl chloride under controlled conditions, purified and dried into a fine powder that is easy to disperse in creams or serums. Because the ingredient is soil-free and cruelty-free it fits well with modern clean beauty standards.
You will most often find Myristoyl Tetrapeptide-46 in leave-on products where prolonged contact with the skin maximizes results. Common formats include lightweight facial serums, richer moisturizers, eye creams, sheet masks and targeted anti-aging treatments aimed at smoothing fine lines or improving firmness.
Myristoyl Tetrapeptide-46’s Cosmetic Benefits/Uses
Formulators choose Myristoyl Tetrapeptide-46 for its ability to give skin a healthier look and feel.
Skin conditioning: This peptide helps the skin stay soft, supple and balanced by supporting its natural repair processes and reinforcing the moisture barrier, which can translate to smoother texture and a fresher appearance over time.
Who Can Use Myristoyl Tetrapeptide-46
This peptide is generally well tolerated by all major skin types including dry, normal, combination and oily because it is lightweight and non occlusive. Sensitive skin usually accepts it too since it has no fragrance or harsh acids, though anyone with a history of peptide allergies should proceed cautiously.
The ingredient is produced entirely through laboratory synthesis without animal byproducts or testing, making it suitable for both vegetarians and vegans.
No data indicate that topical Myristoyl Tetrapeptide-46 poses a special risk during pregnancy or breastfeeding, but this is not medical advice. Expectant or nursing mothers should ask a healthcare professional before adding any new cosmetic product to their routine to be extra safe.
The molecule does not increase photosensitivity so it can be used day or night without boosting sunburn risk, though daily sunscreen is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Myristoyl Tetrapeptide-46 differ from person to person. The following list covers potential side effects though most users will not experience them when the ingredient is formulated and used properly.
- Mild redness or warmth shortly after application
- Temporary itching or tingling as the product dries
- Localized irritation for those with very reactive skin
- Rare allergic contact dermatitis presenting as rash or swelling
- Possible clogged pores or small breakouts in individuals extremely prone to congestion
If any unwanted reaction occurs discontinue use immediately and consult a qualified healthcare provider if symptoms persist or worsen.
Comedogenic Rating
Rating: 1/5
Myristoyl Tetrapeptide-46 itself is a very small part of a finished formula and the peptide backbone does not clog pores. The attached myristic fatty acid could theoretically raise the chance of congestion, but the quantity is so low that any pore-blocking potential is minimal. For most users this translates to a practically non-comedogenic profile.
Suitable for acne-prone or breakout-prone skin in the vast majority of cases.
Real-world performance still depends on the full product formula, so heavier creams using rich oils or waxes may feel less breathable even if the peptide is not the culprit.
Summary
Myristoyl Tetrapeptide-46 is a lab-made peptide linked to a fatty acid that helps it slip into the skin’s surface. Its main job is skin conditioning, which it achieves by supporting barrier repair, boosting softness and giving the complexion a smoother look over time. The ingredient shows up mostly in modern anti-aging serums and eye creams, but it is still considered a niche active rather than a mainstream star.
Safety data so far paints a reassuring picture, with low irritation risk, vegan sourcing and no known hormonal issues. As with any new skincare ingredient it is smart to do a quick patch test before full-face use, especially if your skin is sensitive.