Myristoyl Tripeptide-1: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
Share:
Inside this article:

We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Myristoyl Tripeptide-1?

Myristoyl Tripeptide-1 is a lab made lipopeptide, meaning it pairs a tiny chain of three amino acids with myristic acid, a fatty acid found in nut and seed oils. The fatty part helps the peptide slip through the skin’s surface while the peptide part sends a signal that encourages the skin to look and act younger. Scientists first explored this kind of signal peptide in the late 1990s while searching for gentler options to replace retinol in anti aging care, and the ingredient began showing up in creams and serums in the early 2000s. It is created with solid phase peptide synthesis, a step by step process that builds the amino acid chain, followed by a coupling step that attaches the myristic acid. After purification the finished ingredient is dissolved in a skin friendly solvent and added to formulas. You will most often spot Myristoyl Tripeptide-1 in facial serums, eye creams, sheet masks, overnight moisturizers, lip plumpers and leave on treatments aimed at firming and smoothing the skin.

Myristoyl Tripeptide-1’s Cosmetic Benefits/Uses

As a skin conditioning ingredient Myristoyl Tripeptide-1 helps skin feel softer and look smoother, supports the natural repair process, boosts surface hydration and can lessen the appearance of fine lines when used regularly.

Who Can Use Myristoyl Tripeptide-1

Because it is lightweight and non greasy Myristoyl Tripeptide-1 suits dry, normal, combination and oily skin alike. Sensitive skin usually tolerates it well since it is fragrance free and has a neutral pH though anyone with an especially reactive barrier should introduce it slowly to be sure their skin feels comfortable.

The peptide is produced entirely in the lab without animal derived materials so the raw ingredient itself is vegan and vegetarian friendly. Always double check the finished product’s label in case the brand combines it with animal sourced additives like beeswax or collagen.

No specific warnings exist for topical use during pregnancy or while nursing and it is not related to retinoids or exfoliating acids that commonly raise concern. This is not medical advice so expectant or breastfeeding users should still show any new skincare product to a qualified doctor to confirm it fits their individual needs.

Myristoyl Tripeptide-1 does not make skin more sensitive to sunlight and can be applied morning or night without raising the risk of sunburn. Normal daily sunscreen habits are still recommended to protect the skin overall.

Potential Side Effects/Adverse Reactions

Responses to Myristoyl Tripeptide-1 differ from person to person. The points below cover potential effects yet most people experience none of them when using a well formulated product.

  • Mild redness or warmth right after application
  • Transient itching or tingling as the product absorbs
  • Dry patches if formula contains a high level of alcohol or other drying carriers
  • Allergic contact dermatitis in individuals sensitized to peptides or the product’s preservatives
  • Eye stinging if the product migrates into the eyes

If any uncomfortable reaction develops stop using the product and seek advice from a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 1 / 5

Myristoyl Tripeptide-1 is water soluble and used in very small amounts so it does not clog pores the way heavier oils or waxes can. The myristic acid tail helps the peptide penetrate but its level is too low to create buildup. Because of this the ingredient rarely aggravates blackheads or whiteheads.

Most people who are prone to acne can use products that feature Myristoyl Tripeptide-1 without noticing extra breakouts.

Keep in mind the finished product’s overall formula matters more than any single ingredient. Silicones, rich plant butters or certain fatty alcohols paired with the peptide could still raise the pore clogging risk for some users.

Summary

Myristoyl Tripeptide-1 is a lab made lipopeptide that conditions skin by signaling it to boost its own repair proteins, smoothing texture, softening fine lines and increasing surface moisture. Its slim molecular size and fatty tail let it slip past the outer layer so it can get this message across.

It shows up in a fair number of anti aging serums, eye creams and overnight masks but is not as famous as retinol or vitamin C, making it a quiet yet effective option for anyone looking to firm and hydrate without irritation.

Topical use is considered very safe with low chances of sensitivity or pore clogging. As with any new skincare ingredient it is wise to patch test a product that contains Myristoyl Tripeptide-1 before adding it to your daily lineup to be sure your skin reacts comfortably.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search