What Is Myristoyl Tripeptide-31?
Myristoyl Tripeptide-31 is a small, lab made molecule formed by linking myristic acid, a fatty acid found in coconut oil and nutmeg, with a short chain of three amino acids known as Tripeptide-31. The result is a lipopeptide that can easily mix with the skin’s natural oils, helping it slip into the outer layers of the skin.
The idea of joining fatty acids to peptides began in the early 2000s when researchers looked for ways to deliver peptides more efficiently through the skin. By attaching the lightweight myristic acid, scientists found they could boost skin absorption without the heaviness of larger lipid carriers. Myristoyl Tripeptide-31 soon appeared in premium anti-aging lines as brands searched for new actives that could rival well known peptides like palmitoyl pentapeptide-4.
Manufacturing starts with fermenting plant sugars to make the three amino acids, which are then bonded in a controlled reaction to create Tripeptide-31. Separately, myristic acid is purified from renewable plant oils. A coupling step joins the two parts, followed by filtration and drying to yield a fine, off-white powder that dissolves in cosmetic oils or certain silicones.
You will most often see Myristoyl Tripeptide-31 in leave-on products where close contact with the skin can maximize benefit: lightweight serums, night creams, eye treatments, sheet masks and ampoules aimed at firmness or smoothness. Some brands add it to tinted moisturizers or primers for daily anti-aging support.
Myristoyl Tripeptide-31’s Cosmetic Benefits/Uses
This peptide is prized for its skin conditioning ability, meaning it helps the skin look and feel better overall.
As a skin conditioning agent, Myristoyl Tripeptide-31 can support a softer surface, promote a more even texture and give a supple appearance. By improving skin feel, it enhances the sensory profile of a formula, making the finished product glide on smoothly and leave a light, comfortable finish.
Who Can Use Myristoyl Tripeptide-31
Myristoyl Tripeptide-31 suits most skin types, including dry, normal, combination and mature skin because it is lightweight and non greasy. Oily or acne prone users can usually apply it without feeling heavy or pore clogging, although those highly reactive to any fatty acid derivative may wish to monitor for breakouts. Sensitive skin tends to tolerate the peptide since it is fragrance free and used at low levels, yet very reactive individuals should be cautious with any new active.
The ingredient is synthesized from plant sourced myristic acid and lab fermented amino acids, so it is considered vegan and vegetarian friendly. No animal by products are required in its standard production.
Current data shows no specific risk for women who are pregnant or breastfeeding when the peptide is applied topically at cosmetic concentrations. Still, this is not medical advice and anyone who is pregnant or nursing should discuss all skincare products with a qualified healthcare professional to be safe.
Myristoyl Tripeptide-31 does not make skin more sensitive to sunlight, so it is not classed as a photosensitizer. Standard daytime sunscreen use is still recommended as part of any good routine.
Potential Side Effects/Adverse Reactions
Side effects from topical use of Myristoyl Tripeptide-31 vary from person to person. The issues listed below are possible yet unlikely for most users when the ingredient is properly formulated and used as directed.
- Temporary redness or warmth – a mild flush that normally fades quickly
- Stinging or tingling on application – more common on compromised or freshly exfoliated skin
- Dry patches – rare but can occur if the formula lacks sufficient emollients for very dry skin
- Breakouts or small pustules – potential in those extremely sensitive to fatty acids
- Allergic contact dermatitis – extremely uncommon but possible in individuals with a specific peptide or fatty acid allergy
If any persistent irritation or unexpected reaction develops stop use and consult a healthcare professional.
Comedogenic Rating
Rating: 1 / 5. Myristoyl Tripeptide-31 contains a small amount of myristic acid, a fatty acid that can be mildly occlusive, yet it is attached to a short peptide and used at very low percentages in finished formulas. This greatly reduces any pore-clogging potential compared with pure oils or butters rich in myristic acid. In most well-balanced serums and creams the ingredient is light, absorbs quickly and leaves minimal residue, so it is unlikely to trap debris inside pores.
Overall it is considered suitable for those prone to acne or breakouts, especially when the rest of the formula is non-comedogenic. Formulation quality, the presence of heavy silicones or waxes and the user’s own skin type will still influence the final result.
Summary
Myristoyl Tripeptide-31 is a skin conditioning lipopeptide that helps improve softness, smoothness and overall feel by blending easily with the skin’s natural lipids and supporting a supple surface. It is not as famous as powerhouse peptides like Matrixyl but has carved out a niche in select anti-aging serums, eye creams and K-beauty ampoules thanks to its light texture and compatibility with many bases.
Current evidence shows it is safe for topical use at cosmetic levels with only rare reports of irritation or breakouts. As with any new ingredient, a quick patch test is wise before adding a product featuring Myristoyl Tripeptide-31 to your daily routine just to be on the safe side.