What Is N-Caproyl Tyramine?
N-Caproyl Tyramine is a lab-made derivative of tyramine, a naturally occurring compound found in some plants and foods. Chemically it is known as Hexanamide, N-[2-(4-hydroxyphenyl)ethyl]-, which means a caproic acid chain is attached to the tyramine backbone. This tweak gives the molecule better oil compatibility and stability, features that make it attractive for skin care.
The ingredient first drew attention when researchers were looking for small molecules that could guard the skin against everyday oxidative stress. By the late 2010s formulators began adding it to niche anti-aging serums. Today it appears in a wider range of products thanks to more efficient synthesis methods that couple tyramine with caproic acid under mild, solvent-controlled conditions. The result is a high-purity powder or viscous liquid that blends smoothly into both water-based and oil-based systems.
You will typically spot N-Caproyl Tyramine in facial moisturizers, antioxidant serums, sheet masks, overnight creams, eye treatments and products aimed at supporting skin exposed to pollution or blue light.
N-Caproyl Tyramine’s Cosmetic Benefits/Uses
In formulas, this multitasker offers a few key perks
- Antioxidant: Helps neutralize free radicals created by UV rays, pollution and daily stressors which can otherwise lead to dullness and premature lines. By keeping oxidative damage in check it supports a fresher, more even complexion.
- Skin Protecting: Forms a light defensive film that reinforces the skin barrier, reducing moisture loss and shielding against external irritants. This makes the skin feel smoother and more resilient over time.
Who Can Use N-Caproyl Tyramine
N-Caproyl Tyramine is gentle enough for most skin types. Its light barrier support suits dry, sensitive and mature skin while the non-greasy finish also works for combination or oily skin. People with very reactive or broken skin barriers should introduce it slowly in case the formula contains additional actives that may tingle on open areas.
The ingredient is manufactured synthetically with no animal-derived matter so it is suitable for both vegans and vegetarians. It is also commonly found in products made by cruelty-free brands but you will still need to confirm individual company policies.
Current safety data show no specific concerns for pregnant or breastfeeding women when the ingredient is used topically in standard cosmetic amounts. That said this is not medical advice and anyone who is expecting or nursing should run the full product list by a qualified healthcare professional to be on the safe side.
N-Caproyl Tyramine does not make skin more sensitive to sunlight. Daily sunscreen is still recommended for overall skin health but there is no added need to avoid daylight after applying this antioxidant.
Potential Side Effects/Adverse Reactions
Responses to topical N-Caproyl Tyramine vary from person to person. The points below outline potential side effects yet most users will not encounter them when the ingredient is formulated correctly.
- Mild redness or warmth shortly after application
- Transient stinging around the eyes or on freshly exfoliated skin
- Itching or small bumps in those with a tyramine sensitivity
- Contact dermatitis if paired with very high concentrations of alcohol or fragrance
- Reduced effectiveness of leave-on acids or retinoids if layered without adequate drying time
If any persistent irritation or unexpected reaction occurs stop using the product and consult a healthcare professional
Comedogenic Rating
Rating: 1 / 5
N-Caproyl Tyramine carries a small lipophilic tail that helps it blend into skin oils yet the molecule is lightweight and used at low percentages. Current formulation data and user reports show minimal pore-clogging potential, earning it a near non-comedogenic score of 1.
Suitable for acne-prone and breakout-prone skin, provided the overall product is also low in comedogenic ingredients.
No extra cautions are known for fungal acne as the structure does not provide an easy food source for Malassezia yeast.
Summary
N-Caproyl Tyramine serves mainly as an antioxidant and skin-protecting agent. The phenolic hydroxyl group donates electrons to neutralize free radicals while the attached caproic chain lets it lodge in the skin’s lipid layers where it forms a light protective film that slows moisture loss.
The ingredient is still a niche pick compared with classic antioxidants like vitamin C or E yet its stability and gentle profile are earning it a spot in more modern serums and moisturizers.
Safety studies show a low irritation risk at cosmetic use levels and no links to photosensitivity or hormonal concerns. As with any new skincare product you should perform a quick patch test first to confirm personal compatibility.