Natamycin: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Natamycin?

Natamycin is a naturally occurring antimicrobial compound produced by the soil bacterium Streptomyces natalensis. Chemically it belongs to the polyene macrolide family and has a large ring structure with multiple oxygen atoms that let it bind to and disable unwanted microbes. First identified in the 1950s, it was adopted by the food industry as a mold inhibitor before formulators realized its value for keeping cosmetics fresh. Commercial production starts with a controlled fermentation of the microbe, followed by filtration, solvent extraction and gentle drying to yield a fine off-white powder that dissolves in cosmetic emulsions. Today you will spot it in creams, lotions, sheet masks, deodorants, serums, eye creams and any water-based product that needs reliable protection against spoilage.

Natamycin’s Cosmetic Benefits/Uses

Natamycin adds value to a formula in two main ways

  • Antimicrobial: It targets yeasts and molds that can ruin a product or unsettle skin. By stopping these microbes from growing Natamycin helps keep the texture, scent and color of a product stable throughout its shelf life
  • Preservative: Because it stops microbial growth, Natamycin extends the usable life of a cosmetic and reduces the need for stronger preservative blends. This allows brands to create milder formulas that stay safe for longer on the bathroom shelf

Who Can Use Natamycin

Natamycin is considered gentle enough for most skin types including normal, dry, oily and combination. People with sensitive or allergy-prone skin usually tolerate it well because it sits within the formula rather than on the skin surface and works at very low levels. There are no known skin types that must avoid it outright but anyone with a proven allergy to polyene antifungals should steer clear.

The ingredient is produced by fermenting a natural soil bacterium, then purified without the use of animal-derived materials. For that reason it is suitable for both vegetarians and vegans.

Current data does not flag Natamycin as a risk for pregnant or breastfeeding women when used in rinse-off or leave-on cosmetics. Still, this is not medical advice and anyone who is pregnant or nursing should check with a healthcare professional before adding new products to their routine.

Natamycin does not make skin more sensitive to sunlight, so no special daytime precautions are needed beyond regular sunscreen use.

Potential Side Effects/Adverse Reactions

Reactions to topical Natamycin are rare but can differ from person to person. The points below outline possible side effects which are unlikely for the average user when the ingredient is properly formulated.

  • Mild redness or irritation
  • Itchy feeling at the application site
  • Contact dermatitis in those already allergic to antifungal drugs
  • Eye stinging if the product is accidentally rubbed into the eyes

If you notice any of these issues stop using the product and consult a healthcare professional

Comedogenic Rating

Rating: 0/5

Natamycin is a water-compatible powder used at trace levels so it leaves no greasy film or residue that could block pores. Its structure does not resemble fatty acids or waxes known to contribute to comedones which is why it earns the lowest possible rating.

Suitable for acne-prone or breakout-prone skin.

Because it targets only microbes and has no surfactant or emollient action its pore-clogging potential stays negligible even in rich formulations.

Summary

Natamycin serves mainly as an antimicrobial and preservative, shutting down yeasts and molds by binding to their cell membranes which keeps cosmetics fresh and safe on the shelf.

Although widely used in food, it remains a low-profile but dependable option in skincare where formulators appreciate its effectiveness at tiny doses.

The ingredient is considered very safe with minimal reports of irritation, yet a quick patch test is always wise when trying any new product.

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