What Is Nematode Rh-Polypeptide-47?
Nematode Rh-Polypeptide-47 is a lab engineered peptide originally derived from the common soil nematode Caenorhabditis elegans. Using transgenic biotechnology, scientists insert the specific gene sequence that codes for Polypeptide-47 into microbial cultures. These microbes are then fermented in controlled tanks, allowing them to churn out large amounts of the peptide without relying on animal sources. After fermentation the peptide is purified, filtered and dried into a fine powder that easily dissolves in water based cosmetic formulas.
The ingredient first appeared in research journals in the early 2000s when peptides from nematodes were studied for their ability to bind water and soothe stressed skin. As formulation technology advanced skin care brands began adding Nematode Rh-Polypeptide-47 to hydrating serums and anti-aging creams for its multitasking benefits. Today you will most commonly find it in moisturizers, sheet masks, overnight masks, eye creams, essence lotions and targeted anti-age treatments that promise plumper softer skin.
Nematode Rh-Polypeptide-47’s Cosmetic Benefits/Uses
This multitasking peptide supports several aspects of skin care performance
- Humectant – attracts moisture from the environment and pulls it into the upper layers of the skin which helps keep the complexion looking dewy and reduces the appearance of fine lines caused by dryness
- Skin conditioning – leaves a soft silky feel on the surface while supporting the skin’s natural barrier so the face stays comfortable even in drying conditions
- Emollient – fills in microscopic gaps between skin cells creating a smoother texture which improves slip during application and makes makeup sit better on top
Who Can Use Nematode Rh-Polypeptide-47
Nematode Rh-Polypeptide-47 is generally well tolerated by all major skin types including dry, normal, combination and oily because its water-binding and barrier-support benefits address both dehydration and surface roughness without clogging pores. Sensitive skin can usually use it too since the peptide is non-acidic and fragrance-free, although extremely reactive skin may still prefer a simpler formula.
The ingredient is produced through microbial fermentation without any animal derivatives so it is suitable for both vegans and vegetarians.
Current data does not flag the peptide as problematic for pregnant or breastfeeding women when applied topically. This is not medical advice and anyone who is pregnant or nursing should confirm safety with a healthcare professional before adding new skincare products.
Nematode Rh-Polypeptide-47 does not increase photosensitivity so daytime use does not require extra sun precautions beyond a regular SPF routine.
Potential Side Effects/Adverse Reactions
Responses to topical Nematode Rh-Polypeptide-47 vary by individual. The following outlines potential side effects that are possible yet uncommon when the ingredient is used at standard cosmetic levels.
- Transient redness or warming sensation
- Mild itching or tingling in very sensitive skin
- Localized hives or rash in cases of peptide allergy
- Watery eyes if the formula migrates into the eye area
- Interaction with broken or compromised skin leading to stinging
If any negative reaction occurs stop use immediately and consult a qualified healthcare provider.
Comedogenic Rating
Rating: 0 / 5
Nematode Rh-Polypeptide-47 is a small water-soluble peptide with no oils, waxes or heavy film formers so it does not block pores or trap sebum. Its primary actions focus on hydration and surface conditioning rather than forming an occlusive layer that could encourage comedone formation. For these reasons it earns a solid zero on the comedogenic scale and is considered suitable for acne-prone or breakout-prone skin.
The only caveat is that finished products often pair the peptide with other ingredients. Always look at the full ingredient list if pore clogging is a concern.
Summary
Nematode Rh-Polypeptide-47 is a lab cultured peptide that acts as a humectant, skin conditioner and light emollient. It grabs onto water molecules to keep skin hydrated, smooths micro-roughness by filling gaps between cells and supports the barrier so skin feels soft and resilient. Its water-soluble nature lets formulators drop it into serums, creams and masks without needing heavy oils.
While not as famous as hyaluronic acid or ceramides the peptide has quietly gained traction in mid to premium hydrators where brands want a vegan biotech story and a silky finish without stickiness.
Topical use is generally considered low risk thanks to its non-allergenic profile and zero comedogenic rating. That said everybody’s skin is unique so it is wise to patch test any new product that contains Nematode Rh-Polypeptide-47 before applying it to the entire face.