What Is Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1?
Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1 is a lab designed fusion of two short protein chains. One part is Hexapeptide-40, a six-amino-acid fragment, and the other is a single chain replica of human Epidermal Growth Factor. Scientists insert the human gene into the leaves of the Nicotiana benthamiana plant, a relative of the tobacco family, using either a temporary expression system or stable genetic insertion. The plant acts like a natural factory, producing the peptide which is then harvested, purified and blended into cosmetic formulas. Because the resulting fusion peptide keeps the same 20 standard amino acids found in our skin, it can slip comfortably into skincare products. First explored by biotech researchers looking for plant based ways to make human proteins, the ingredient found a home in beauty labs seeking gentle yet effective skin rejuvenators. Today it turns up in serums, anti-aging creams, sheet masks, targeted eye treatments and soothing post-procedure gels where it aims to leave skin looking smoother and more refreshed.
Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1’s Cosmetic Benefits/Uses
This peptide is valued for one main role in skincare formulations.
Skin conditioning: it helps support a healthy moisture barrier, promotes a supple feel and can contribute to a fresher, more even complexion. By mimicking signals naturally present in the skin it encourages surface renewal, which may soften the look of fine lines and improve overall texture, giving products a more youth-boosting edge.
Who Can Use Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1
This peptide suits most skin types including dry, normal, combination and oily because it is lightweight and non-occlusive. People with very reactive or highly sensitive skin generally tolerate it well, yet anyone with a known allergy to tobacco family plants or to peptide ingredients should proceed carefully since trace plant proteins could linger in a finished formula.
The ingredient is produced in Nicotiana benthamiana leaves without any animal-derived materials so it is considered appropriate for vegans and vegetarians.
Current topical data raise no specific red flags for women who are pregnant or breastfeeding, but research is limited. This article is not medical advice; expectant or nursing mothers should show the product to their healthcare provider before adding it to a routine.
Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1 does not make skin more prone to sunburn, so it is not classed as photosensitising. Standard daytime sun protection is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Individual responses to Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1 vary. The following list covers potential but uncommon effects when the ingredient is used as intended in a cosmetic formula. Most people will not experience these issues.
- Temporary redness or warmth at the application site
- Mild stinging or itching, especially on compromised skin
- Dry patches if the formula combines the peptide with strong exfoliating acids
- Allergic contact dermatitis in those sensitive to tobacco family proteins or specific amino acid sequences
- Eye irritation if the product migrates into the eyes
If any of these reactions occur stop using the product and consult a healthcare professional if symptoms persist or worsen.
Comedogenic Rating
Rating: 0 / 5. Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1 is a water-soluble peptide that contains no oils, waxes or fatty acids known to block pores. It is used at very low concentrations and is easily rinsed from the skin during normal cleansing so it carries virtually no risk of clogging follicles. Trace plant proteins left from the manufacturing process are also water-based and do not add to occlusion.
Because it sits at the bottom of the comedogenic scale this ingredient is generally suitable for those who are prone to acne or breakouts.
Formulators sometimes combine the peptide with richer emollients to build a silky texture; if a finished product feels heavy the breakout risk is more likely tied to those other ingredients than to the peptide itself.
Summary
Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1 is a lab-crafted fusion peptide that conditions skin, supports a healthy moisture barrier and nudges surface renewal by echoing the signals of human Epidermal Growth Factor. In turn it can soften the look of fine lines and improve overall smoothness.
It is a niche yet rising star in biotech beauty. You will mostly see it in mid to high-end serums, masks and post-treatment balms rather than on every drugstore shelf, but its plant-based production and gentle profile are drawing attention.
Current data show it is well tolerated with minimal side effects for most users. As with any new skincare ingredient it is best to patch test a product first to make sure your skin agrees with the formula.