What Is Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47?
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47 is a lab designed fusion peptide made in the leaves of the Nicotiana benthamiana plant, a relative of the tobacco plant that is often used in modern biotech. Scientists insert a copy of the human gene that codes for part of collagen into the plant. The plant then acts as a tiny factory, producing a 116 amino acid protein that blends a collagen inspired segment with a smaller six amino acid peptide. After the leaves grow the protein is extracted, carefully purified and adjusted to suit skin care formulas.
Using plants to craft human style peptides is a fairly new approach that rose to popularity as brands searched for sustainable ways to make high performance ingredients. Because the process avoids animal sources and uses controlled indoor farms, it can yield a pure consistent peptide ready for cosmetic use.
You will most often see Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47 in anti aging serums, firming creams, hydrating masks, concentrated ampoules and targeted eye treatments where a boost of collagen like activity is desired.
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47’s Cosmetic Benefits/Uses
The main role of this ingredient in skin care is skin conditioning, which means it helps the surface of the skin feel smoother, softer and better hydrated. By mimicking a fragment of collagen it can support the skin’s own matrix, which may lessen the look of fine lines and give the complexion a firmer more supple appearance.
Who Can Use Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47
This peptide is generally suitable for all skin types, including dry, oily, combination and sensitive skin, because it focuses on hydration and support rather than exfoliation or heavy occlusion. Those with highly reactive or allergy-prone skin should still pay attention to the full ingredient list of a finished product to ensure no added fragrances or preservatives pose an issue.
Because it is produced in a plant host and contains no animal derived material, products featuring Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47 are typically appropriate for vegans and vegetarians. Manufacturers often highlight this point on packaging or in marketing copy.
No specific warnings have been issued for pregnant or breastfeeding women, but data on newer bioengineered peptides is limited. This information is not medical advice; anyone who is pregnant or nursing should discuss any skin care product with a qualified health professional before use.
The ingredient is not known to cause photosensitivity, so it will not make skin more prone to sunburn. Standard daytime sun protection is still recommended whenever you use any anti aging routine.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical application of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47 can vary from person to person. The points below outline potential issues, yet most users will not experience them when the ingredient is formulated and used correctly.
- Temporary redness or mild stinging immediately after application
- Localized irritation if applied to broken or highly compromised skin
- Allergic response in individuals sensitive to plant proteins or residual plant compounds
- Contact dermatitis triggered by other ingredients in the same formula rather than the peptide itself
If you experience any of these negative effects discontinue use and seek advice from a medical professional.
Comedogenic Rating
Rating: 0 / 5
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47 is a water-soluble peptide with no oily or waxy components so it does not clog pores on its own. That places it at the bottom of the comedogenic scale.
Because of this low rating the ingredient is generally suitable for skin that breaks out easily or is prone to acne.
Keep in mind that a finished product’s overall pore-clogging potential depends on every ingredient in the formula not just the peptide.
Summary
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47 is a plant-made peptide designed to condition skin by mimicking a fragment of collagen. It helps skin feel smoother stay better hydrated and look a bit firmer by supporting the surface matrix.
The ingredient is still fairly new so you will not find it in every aisle yet but its sustainable production and high-tech appeal are drawing attention in premium serums and creams.
Current data shows it is well tolerated with a very low risk of irritation or clogged pores. As with any new skin care step it is wise to patch test a product that contains this peptide before using it on your whole face.