What Is Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-6?
Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-6 is a lab crafted peptide that blends two parts: Hexapeptide-40 and a small version of the human protein interleukin-10. Instead of taking this protein from people the gene that codes for it is copied and placed into the leaves of a harmless tobacco relative called Nicotiana benthamiana. The plant acts like a green factory making the peptide in a short growth cycle. After harvest the leaves are crushed, the protein is filtered out, then purified to remove plant material, color and scent. The finished ingredient is a chain of up to 166 amino acids that may form natural bridges called disulfide bonds and can carry small sugar groups, all of which help it keep its shape and activity.
Using plants to grow cosmetic peptides is fairly new. The method gained attention in the last decade because it avoids animal sources, can be scaled up quickly and keeps costs under control. Brands looking for gentle bio-based actives began adding this peptide to formulas that target redness, dryness and early signs of aging.
You will most often see Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-6 in soothing serums, anti aging creams, sheet masks, post-treatment gels, daily moisturizers for sensitive skin and after-sun lotions where calm, comfort and smooth feel are top priorities.
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-6’s Cosmetic Benefits/Uses
This ingredient is prized for one main job in skin care.
As a skin conditioning agent it helps the skin feel soft, supple and balanced. By supporting the skin’s natural barrier and signaling a more peaceful environment it can reduce the look of redness, ease tightness and leave the surface smoother to the touch. Products that include it often claim quick comfort for stressed or reactive skin and a healthier hydrated appearance over time.
Who Can Use Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-6
This peptide suits most skin types including dry, normal, combination, oily and especially sensitive or redness-prone skin because its main role is to calm and condition without adding heavy oils or exfoliating acids. There are no known reasons it would be unsuitable for any specific skin type, though anyone with a documented allergy to tobacco plant proteins should approach with caution since the peptide is grown in Nicotiana benthamiana leaves.
The ingredient is plant produced and free from animal derivatives so it is generally considered appropriate for vegans and vegetarians.
Current data shows no specific risks for pregnant or breastfeeding women when the peptide is used topically in cosmetic concentrations. This is not medical advice and anyone who is pregnant or nursing should discuss any new skincare product with a doctor to be on the safe side.
The peptide does not absorb UV light and has no known link to photosensitivity so it will not make skin more prone to sunburn. Standard daytime sun protection is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-6 differ from person to person. The effects listed below are possible but unlikely for most users when the ingredient is properly formulated and preserved.
- Mild redness or warmth – usually brief and self-resolving as the skin adjusts
- Itching or tingling – may occur in very sensitive individuals
- Allergic contact dermatitis – rare but possible for those with a specific sensitivity to peptide sequences or residual plant proteins
- Hives or swelling – extremely uncommon yet can occur with any protein based ingredient
- Interaction with highly active exfoliants – layering immediately after strong acids or retinoids could momentarily heighten stinging in reactive skin
If any of these effects develop stop use immediately and consult a healthcare professional or dermatologist for guidance.
Comedogenic Rating
Rating: 0/5. Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-6 is a large water-soluble peptide with no oily or waxy components that could clog pores. It sits on the skin surface to deliver soothing signals then rinses away easily during cleansing, so it earns the lowest possible score for pore blockage risk. This makes it a safe choice for those prone to acne or breakouts.
As with any ingredient the final formula matters. Heavy occlusive bases or rich plant butters paired with this peptide could still trigger congestion for some users, but the peptide itself is non-comedogenic.
Summary
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-6 is a plant-made fusion peptide that conditions skin by supporting the barrier, calming visible redness and leaving the surface soft and balanced. It works through gentle bio-signals that encourage a less reactive environment while adding a light hydrating feel.
Its popularity is modest but climbing as biotech ingredients gain traction with brands looking for vegan sustainable actives that soothe sensitive skin.
Current data points to a very low irritation profile and no comedogenicity concerns, making it broadly safe for daily use across skin types. Still, skin can be unpredictable, so it is wise to patch test any new product that features this ingredient before applying it to the entire face.