What Is Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76?
Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76 is a lab-designed peptide that blends two parts: Hexapeptide-40 and a single-chain version of the human protein Transforming Growth Factor Beta-2. Scientists insert the human gene sequence into the leaves of the Nicotiana benthamiana plant, which acts like a tiny factory to grow the protein. After the plants mature the peptide is extracted, purified and then combined with Hexapeptide-40 to create the finished ingredient.
This plant-based production method began gaining attention in the early 2000s when researchers were looking for cleaner, more sustainable ways to make complex peptides. Over time, cosmetic chemists noticed that the resulting fusion peptide helped skin look smoother and better hydrated, leading to its use in topical formulas.
Today you will most often see Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76 in anti-aging serums, firming creams, concentrated ampoules, sheet masks and targeted eye treatments, where it works alongside other actives to improve overall skin feel and appearance.
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76’s Cosmetic Benefits/Uses
In skin care formulas this ingredient serves one main purpose, which is skin conditioning.
As a skin-conditioning agent it helps soften and smooth the surface of the skin, supports a more even texture and can enhance the comfortable feel of a product after application. When used consistently it can contribute to a healthier-looking, well-moisturized complexion, making it a popular choice in products aimed at reducing the visible signs of aging.
Who Can Use Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76
This peptide is gentle enough for most skin types including dry, normal, combination and oily skin. People with sensitive skin generally tolerate it well since it is non exfoliating and fragrance free, though anyone with known plant allergies should read a product’s full ingredient list before use.
Because the peptide is grown in tobacco plant leaves yet contains no animal derived substances, it is suitable for both vegans and vegetarians. Production relies on plant biotechnology rather than animal collagen or serum, aligning with cruelty free preferences.
Current data does not flag any special concerns for pregnant or breastfeeding women when the ingredient is applied topically. Absorption into the bloodstream is expected to be minimal however safety studies specific to this group are limited. This information is not medical advice so expectant or nursing mothers should ask their healthcare provider before adding any new skincare product.
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76 is not known to increase photosensitivity so it can be used morning or night. It layers smoothly with common actives such as hyaluronic acid, peptides, niacinamide and non exfoliating antioxidants.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical application of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76 can vary from person to person. The points below outline potential issues but they remain uncommon when the ingredient is properly formulated and used as directed.
- Mild transient redness
- Localized rash or hives in individuals with plant sensitivities
- Allergic contact dermatitis in very rare cases
- Swelling if the product is applied to broken or compromised skin
If a negative reaction occurs discontinue use and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0 – Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76 is a small, water-soluble peptide that sits lightly on the skin and rinses away easily. It contains no heavy oils, waxes or fatty alcohols that could block pores, so it earns the lowest possible score.
This makes the ingredient a comfortable option for those who are prone to acne or frequent breakouts.
Because it is normally used at low concentrations and paired with oil-free delivery systems, its presence does not change the pore-clogging potential of most formulas.
Summary
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76 is a lab-grown fusion peptide used mainly for skin conditioning. By mimicking signals linked to Transforming Growth Factor Beta-2, it helps skin feel smoother, look more even and stay better hydrated. The result is a soft, plump appearance that can lessen the look of fine lines over time.
The ingredient is still niche, showing up in select anti-aging serums and masks rather than on every store shelf, yet formulators who want plant-based peptides are turning to it more each year.
Current research finds it to be low risk for irritation, allergy and pore blockage when used as directed. Even so, it is smart to patch test any new product so your skin can confirm its own comfort level.