What Is Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9?
Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-9 is a lab designed fusion of two parts: Hexapeptide-40, a short chain of six amino acids, and a longer human peptide that mimics vascular endothelial growth factor A. Scientists insert the gene that codes for this human peptide into the leaves of the Nicotiana benthamiana plant, a relative of the tobacco plant widely used in biotech research. The plant becomes a natural factory, producing the combined peptide in its cells. After the leaves are harvested the peptide is extracted, purified and blended into cosmetic formulas.
This plant based production method took off in the early 2000s when researchers were looking for faster, cleaner ways to make complex proteins without relying on animal or bacterial systems. Because the process is scalable and the plant grows quickly it soon found a place in skincare innovation. Today the ingredient appears in leave-on hair conditioners, scalp serums, strengthening masks and multi-benefit treatments aimed at improving hair feel and appearance.
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9’s Cosmetic Benefits/Uses
The main job of this peptide in beauty products is hair conditioning. It helps smooth the cuticle, boosts softness and can support a healthier looking scalp which together leave hair easier to comb, shinier and less prone to breakage.
Who Can Use Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9
This peptide suits nearly every scalp type including dry, oily, color treated and sensitive because it is non-occlusive and lightweight. There are no known issues for people with eczema or psoriasis, though anyone with a history of plant allergies should read the full ingredient list to rule out added fragrances or botanicals that might bother them.
The molecule is produced in a plant and is not sourced from animals, making it acceptable for vegetarians and vegans. No animal testing is required for its production in most regions, which also aligns with cruelty free standards.
Current data shows no specific risks for pregnant or breastfeeding women when the ingredient is used topically in rinse-off or leave-on hair products. Absorption through the skin is expected to be minimal, yet this is not medical advice and those who are pregnant or nursing should ask their physician before starting any new cosmetic product just to be safe.
Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-9 does not make skin or scalp more sensitive to sunlight, so extra sun protection is not needed because of this ingredient alone. It is also compatible with common hair actives like panthenol, keratin, niacinamide and mild acids.
Potential Side Effects/Adverse Reactions
Reactions to topical Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-9 vary from person to person. The points below list potential side effects, though most users will not experience them when the product is formulated and used correctly.
- Scalp redness or mild irritation
- Itching or tingling at the application site
- Allergic contact dermatitis in individuals sensitive to tobacco related proteins
- Stinging if applied to broken or compromised skin
- Rare follicular congestion if the formula also contains heavy oils or waxes
If any of these side effects occur stop using the product and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0. Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-9 is a water-based peptide with no oils, waxes or fatty acids so it does not clog pores on its own. It dissolves fully in the watery phase of a formula and rinses clean if used in a wash-off product.
This low rating means the ingredient is generally safe for skin that breaks out easily.
Keep in mind the final product could still be pore-clogging if it contains heavy butters or silicones so always check the full ingredient list.
Summary
Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-9 works as a hair conditioner that smooths the cuticle, boosts softness and supports a comfortable scalp. Its small size lets it sit on the hair shaft and form a light film that reduces friction while the VEGF-like segment may give the scalp a more balanced feel.
The peptide is still a niche player compared with classics like panthenol or keratin yet interest is rising because plant-made peptides are viewed as clean and high tech.
Overall safety is high with very low risk of irritation for most users. As with any new cosmetic ingredient it is smart to do a quick patch test before full use especially if you have sensitive skin.