What Is Nicotiana Benthamiana Octapeptide-30 Sh-Oligopeptide-2?
Nicotiana Benthamiana Octapeptide-30 sh-Oligopeptide-2 is a lab designed fusion protein made in leaves of Nicotiana benthamiana, a small relative of the tobacco plant often used as a biotech “mini factory.” Scientists insert a human gene that codes for insulin-like growth factor 1 along with the short anti-spot peptide Octapeptide-30. The plant then grows a 68-amino-acid peptide that matches the standard twenty amino acids found in our own bodies and may form helpful disulfide bonds or light sugar links for stability.
The idea of using plants to produce human-identical proteins took off in the early 2000s as a cleaner, animal-free way to make complex actives. Cosmetic brands picked it up once researchers noticed that growth-factor-style peptides could improve skin feel and support stronger hair when applied topically. Today the ingredient is made by growing the modified plants in controlled greenhouses, harvesting the leaves, then extracting and purifying the peptide with food-grade solvents and filtration. After quality checks it is added to water-based formulas, often protected inside liposomes or other carriers so it stays active until it meets your skin or scalp.
You will most often spot Nicotiana Benthamiana Octapeptide-30 sh-Oligopeptide-2 in anti-aging serums, brightening creams, sheet masks, leave-on conditioners, scalp tonics and high-performance moisturizers that promise smoother skin tone or fuller looking hair.
Nicotiana Benthamiana Octapeptide-30 Sh-Oligopeptide-2’s Cosmetic Benefits/Uses
This plant-made peptide brings two key functions that improve the feel and appearance of both skin and hair
- Hair conditioning: Helps coat and reinforce the hair fiber so strands feel softer, resist breakage and look shinier. Suitable for leave-in sprays, masks and serums targeting weak or thinning hair.
- Skin conditioning: Supports a smoother, more hydrated surface by helping the skin hold water and by signaling for a fresher, more even complexion. Often used in serums and creams that target fine lines or uneven tone.
Who Can Use Nicotiana Benthamiana Octapeptide-30 Sh-Oligopeptide-2
This gentle, water-soluble peptide suits nearly every skin type including oily, dry, combination and sensitive because it is non-occlusive and fragrance free. People with a known allergy to peptides or plant proteins should proceed cautiously, as rare cross-reactions can occur.
The ingredient is produced entirely in plants with no animal-derived materials, making it appropriate for both vegetarians and vegans.
No data links the topical use of this peptide to problems during pregnancy or while breastfeeding. The molecule is large and stays mostly on the surface so systemic absorption is unlikely, yet this is not medical advice and anyone who is pregnant or nursing should review new skincare products with a healthcare professional first.
Nicotiana Benthamiana Octapeptide-30 Sh-Oligopeptide-2 does not cause photosensitivity, so it will not make skin more prone to sunburn. It can be layered with sunscreen and most other active ingredients without special timing or precautions.
Potential Side Effects/Adverse Reactions
Side effects from topical Nicotiana Benthamiana Octapeptide-30 Sh-Oligopeptide-2 differ from person to person. The issues listed below are uncommon and most users experience none of them when the ingredient is formulated and preserved correctly.
- Mild redness or warmth shortly after application
- Transient itching or tingling in sensitive skin
- Rare allergic contact dermatitis presenting as rash or swelling
- Eye irritation if the product unintentionally gets into the eyes
- Increased breakouts in acne-prone individuals if the formula pairs the peptide with heavy occlusives
If any of these reactions occur stop using the product and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0 (non-comedogenic). Nicotiana Benthamiana Octapeptide-30 Sh-Oligopeptide-2 is a small, water-soluble peptide that does not contain heavy oils, waxes or fatty alcohols known to block pores. Because it stays on the surface and is readily rinsed away with normal cleansing, it does not build up inside follicles or encourage blackheads.
Suitable for acne-prone skin. Those who struggle with breakouts can generally use formulas featuring this peptide without added risk, provided the rest of the product is also low in pore-clogging ingredients.
Formulators often pair peptides with lightweight gels or serums which keeps the overall product profile friendly to congested or oily skin.
Summary
Nicotiana Benthamiana Octapeptide-30 Sh-Oligopeptide-2 conditions skin by signaling for better moisture retention and a smoother surface and conditions hair by coating and reinforcing each strand for softness and shine. It achieves these effects through its growth-factor-inspired amino acid sequence that interacts with the outer layers of skin and hair without penetrating deeply.
While plant-made growth factor peptides are gaining attention, this specific fusion remains a niche ingredient seen mostly in premium serums, masks and scalp treatments rather than mass market lines.
Overall safety is high. The molecule is non-comedogenic, vegan and unlikely to cause irritation for most users. Still, whenever trying a new cosmetic it is wise to patch test first to confirm personal compatibility.