What Is Nicotiana Benthamiana Sh-Polipedtide-45?
Nicotiana Benthamiana Sh-Polipedtide-45 is a lab designed copy of a natural human protein called Granulocyte Macrophage Colony Stimulating Factor. To make it, scientists insert the human gene that codes for this protein into the leaves of a small tobacco relative known as Nicotiana benthamiana. The plant then acts like a miniature factory, producing a single chain peptide made of up to 144 amino acids that can include natural links called disulfide bonds as well as light sugar decorations known as glycosylation. Once the leaves have built enough of the peptide, it is harvested, purified and blended into cosmetic formulas.
Using plants to grow human peptides is fairly new. Early work focused on producing medicines, but the same gentle growth method soon caught the attention of skin care labs looking for advanced yet sustainable ingredients. Today you will find Nicotiana Benthamiana Sh-Polipedtide-45 in high end serums, firming creams, sheet masks, post-treatment balms and other anti-aging products that aim to refresh the look and feel of tired skin.
Nicotiana Benthamiana Sh-Polipedtide-45’s Cosmetic Benefits/Uses
This plant made peptide is prized for one main job in skin care products.
As a skin conditioning agent it helps skin feel smoother, appear more supple and maintain a healthy level of hydration. Brands include it to support a fresh complexion, soften the look of fine lines and boost overall comfort especially in formulas designed for mature or stressed skin.
Who Can Use Nicotiana Benthamiana Sh-Polipedtide-45
Nicotiana Benthamiana Sh-Polipedtide-45 is gentle enough for most skin types. Its lightweight, water based profile works well on oily and combination complexions, while its ability to support moisture retention benefits dry or mature skin. Sensitive skin usually tolerates the peptide, though those with a known allergy to tobacco related plants should proceed with caution because trace plant proteins could remain after purification.
The peptide is produced entirely in plants with no animal derived inputs, making it suitable for vegans and vegetarians even though the gene template is human.
No studies suggest specific risks for pregnant or breastfeeding women when the ingredient is applied topically and in typical cosmetic concentrations. Because individual medical situations differ this is not medical advice and anyone expecting or nursing should confirm product choices with a qualified healthcare provider.
Nicotiana Benthamiana Sh-Polipedtide-45 does not cause photosensitivity, so daytime use is fine as long as normal sun protection practices are followed. It layers smoothly under sunscreen and makeup and plays well with common actives such as niacinamide and hyaluronic acid.
Potential Side Effects/Adverse Reactions
Reactions to topical Nicotiana Benthamiana Sh-Polipedtide-45 vary from person to person. The effects listed below are possible, not probable, and most users will experience none of them when the ingredient is correctly formulated and used as directed.
- Mild redness or temporary irritation, most often in very reactive skin
- Allergic contact dermatitis in individuals sensitive to tobacco plant proteins or certain preservatives present in the finished product
- Transient stinging or warmth if applied to freshly exfoliated, shaved or broken skin
- Rare cross reaction in people with a documented allergy to pharmaceutical Granulocyte Macrophage Colony Stimulating Factor
If you experience any persistent burning, swelling or rash, stop using the product and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0/5 – non comedogenic. Nicotiana Benthamiana Sh-Polipedtide-45 is a large, water soluble peptide free of oils, butters or fatty acids that can block pores. It is used in tiny amounts and sits on the skin surface without mixing with sebum, so it does not encourage blackheads or breakouts.
This makes the ingredient friendly for acne prone and congestion prone skin.
Keep in mind the final product formula matters too, as some creams that house the peptide may include richer emollients that carry their own clogging risk.
Summary
Nicotiana Benthamiana Sh-Polipedtide-45 is a plant grown version of a human signaling protein added to skincare to condition skin, boost softness and help it hold water. Its gentle, bio inspired action helps smooth fine lines and calm stressed complexions.
Although not as famous as mainstream peptides, it is steadily appearing in boutique serums, sheet masks and post procedure balms thanks to its eco conscious production and promising results.
Available safety data shows a low risk of irritation, no comedogenicity and broad suitability across skin types including vegan users. Still, patch testing any new product that features Nicotiana Benthamiana Sh-Polipedtide-45 is a smart move for peace of mind and healthy skin.