What Is Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40?
Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40 is a lab designed protein that blends a short chain of six amino acids, called Hexapeptide-40, with a larger single-chain peptide modeled after a human protein known as Tissue Inhibitor of Metalloproteinases-2. To make it, scientists copy the exact human gene that gives instructions for this skin-friendly protein, then place that gene into the leaves of the Nicotiana benthamiana plant, a relative of the tobacco plant often used in biotech. The plant acts like a mini factory, producing the fusion peptide, which is then harvested, purified, and prepared for use in skin care. The final ingredient contains 200 amino acids that may include natural links like disulfide bonds or sugar attachments, giving it stability and a skin-compatible profile.
This plant-based production method took off in the past decade as brands looked for sustainable ways to create complex peptides without using animal material. Because the protein mimics a natural human skin regulator, formulators have been eager to add it to products that aim to keep skin looking firm and smooth. You will most often find Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40 in anti-aging serums, firming creams, sheet masks, eye treatments, and high-performance moisturizers where it supports the overall feel and appearance of healthy skin.
Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40’s Cosmetic Benefits/Uses
This ingredient is prized in skin care for one key role
Skin conditioning: By resembling a natural skin protein that helps manage enzymes breaking down collagen, the peptide supports a smoother firmer surface. When included in a formula it can help skin retain elasticity, soften fine lines, and promote a refreshed look, making the overall product feel more nourishing and youth-enhancing.
Who Can Use Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40
This lab grown peptide is generally well tolerated by all skin types including dry, oily, combination and sensitive skin because it does not add oil, fragrance or harsh exfoliating acids. Extremely reactive or allergy prone users should still stay alert to any plant protein sensitivities since the peptide is produced in tobacco relative leaves.
Because production happens entirely in plants with no animal derived components the ingredient suits both vegans and vegetarians.
Current research shows no specific risks for pregnant or breastfeeding women when the protein is applied topically. That said this is not medical advice and anyone who is expecting or nursing should run any skincare products they use past a qualified doctor to be safe.
The peptide does not increase photosensitivity so it can be used morning or night. It also layers well with common actives like niacinamide or hyaluronic acid without performance issues.
Potential Side Effects/Adverse Reactions
Responses to topical Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40 vary from person to person. The points below list potential side effects that are unlikely for most users when the ingredient is correctly formulated and used as directed.
- Temporary redness or warmth at the application site
- Mild itching or tingling in very sensitive skin
- Allergic contact dermatitis in individuals with plant protein allergies
- Rash or hives in rare cases of immune sensitivity
- Eye irritation if the product accidentally gets into the eyes
If any negative reaction appears stop using the product immediately and seek advice from a healthcare professional.
Comedogenic Rating
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Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40 is a large water-soluble protein that contains no oils, waxes or fatty acids, so it does not cling to pores or create the kind of occlusive film that can trap sebum and debris. Because it functions strictly as a skin-conditioning peptide and is used at low concentrations, it is considered non-comedogenic.
This makes it appropriate for acne-prone or breakout-prone skin.
The only caveat is the formula surrounding the peptide. Heavy creams or other comedogenic ingredients in the same product could still cause congestion even though the peptide itself is innocuous.
Summary
Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40 is a lab grown fusion peptide that mimics the human Tissue Inhibitor of Metalloproteinases-2, helping to keep the enzymes that break down collagen in check. By doing so it conditions skin, supports firmness and softness and promotes a smoother look.
While not yet a household name it is gaining traction in premium serums and eye creams as brands explore plant-based biotech actives that offer targeted anti-aging benefits without animal sourcing.
Current data shows it is generally safe for all skin types with a very low risk of irritation or pore blockage. As with any new skincare ingredient it is wise to perform a small patch test before full use to ensure personal compatibility.