What Is Nicotinoyl Sh-Pentapeptide-19?
Nicotinoyl Sh-Pentapeptide-19 is a lab-crafted molecule formed by bonding niacin, a form of vitamin B3, with a short chain of five amino acids known as Sh-Pentapeptide-19. By linking the vitamin to the peptide, chemists create a hybrid ingredient that can deliver the skin-supporting qualities of both components in one stable package. The idea first emerged in the early 2000s when peptide research took off in the cosmetic world, and formulators started exploring ways to pair familiar vitamins with new signal peptides to heighten their effects.
Production begins with synthesizing the precise pentapeptide sequence in a controlled lab setting. The peptide then undergoes a coupling reaction with niacin, resulting in a uniform compound that is purified, dried and milled into a fine powder ready for use. Because it is made entirely through laboratory processes, there is no reliance on animal or plant harvesting, which helps maintain batch consistency and minimizes contamination risks.
Nicotinoyl Sh-Pentapeptide-19 is mainly included in anti-aging serums, firming creams, sheet masks and eye treatments aimed at softening the look of wrinkles and rough patches. You might also find it in lightweight emulsions or ampoules that target early signs of skin fatigue.
Nicotinoyl Sh-Pentapeptide-19’s Cosmetic Benefits/Uses
This ingredient is valued for its ability to improve how skin looks and feels in everyday skincare formulas.
As a skin conditioning agent, Nicotinoyl Sh-Pentapeptide-19 helps maintain a smooth, supple surface. The peptide segment encourages the skin’s own renewal processes while the niacin part supports an even tone and healthy barrier. Together they leave skin feeling softer, appearing more resilient and better able to hold moisture, which can translate to a fresher, plumper complexion over time.
Who Can Use Nicotinoyl Sh-Pentapeptide-19
Nicotinoyl Sh-Pentapeptide-19 is generally suitable for all skin types, including oily, combination, normal, dry and even sensitive skin. It is lightweight, non-oily and classed as low risk for clogged pores, so those who struggle with breakouts can usually use it without worry. People with highly reactive or compromised skin should introduce it slowly, as any new active may cause temporary tingling.
The ingredient is created entirely through laboratory synthesis with no animal-derived materials. That makes it appropriate for vegans and vegetarians, provided the finished product also meets cruelty-free standards.
No specific warnings link Nicotinoyl Sh-Pentapeptide-19 to pregnancy or breastfeeding concerns. Current data suggest it does not penetrate deeply or affect hormone levels. Still, this is not medical advice and pregnant or nursing individuals should check with a healthcare provider before adding any new skincare step just to be safe.
Nicotinoyl Sh-Pentapeptide-19 does not increase skin’s sensitivity to sunlight, so it will not make you burn faster. Daily sunscreen remains important for overall skin health, but the peptide itself is not photosensitizing.
Potential Side Effects/Adverse Reactions
Side effects from topical Nicotinoyl Sh-Pentapeptide-19 differ from person to person. The points below outline potential issues only. Most users will not experience them when the ingredient is used at standard cosmetic levels.
- Temporary redness or warmth (niacin flush)
- Mild itching or tingling shortly after application
- Dry or tight feeling if the formula lacks enough emollients
- Rare allergic reaction leading to swelling or hives
- Increased stinging when layered with strong exfoliating acids or retinoids
If any of these reactions occur stop using the product and seek guidance from a medical professional.
Comedogenic Rating
Rating: 0 / 5
Nicotinoyl Sh-Pentapeptide-19 is water soluble and does not contain heavy oils or waxes that can lodge in pores. Peptides sit on the skin surface and niacin is a small vitamin that absorbs quickly, so together they pose very little clogging risk. It is therefore considered non-comedogenic and suitable for acne-prone or breakout-prone skin.
Because it is typically used at low concentrations and often paired with lightweight gel or serum formulas, the overall product texture also stays friendly to congested skin. Only other ingredients in the finished product, such as rich butters or occlusive silicones, are likely to shift the pore-clogging profile.
Summary
Nicotinoyl Sh-Pentapeptide-19 functions mainly as a skin conditioning agent. The pentapeptide segment signals the skin to support natural renewal, while the niacin fragment reinforces barrier strength and a more even tone. In combination they help skin feel smoother, hold moisture better and look fresher over time.
It is not a household name like retinol or vitamin C, but formulators appreciate its stability and gentle action, so it appears in a growing number of modern serums and eye creams aimed at early aging concerns.
Current safety data show low irritation potential, no photosensitivity and no known hormonal effects. As with any new active, patch testing a small area first is wise to rule out personal sensitivity before full-face use.