Nicotinoyl Sh-Pentapeptide-4: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Nicotinoyl Sh-Pentapeptide-4?

Nicotinoyl Sh-Pentapeptide-4 is a lab made blend that links niacin, better known as vitamin B3, with a short chain of five amino acids called a pentapeptide. Joining the vitamin to the peptide helps the small protein get into the skin while adding the brightening power of niacin.

The idea of pairing vitamins with peptides gained ground in the early 2000s when brands looked for gentler options to even skin tone and soften lines. Chemists found that bonding niacin to a bio-engineered peptide kept both parts stable and let them work in low doses, so Nicotinoyl Sh-Pentapeptide-4 started showing up in skin care soon after.

The ingredient is produced in a controlled lab process. First the pentapeptide is grown through solid-phase synthesis, a step by step method that strings amino acids together. Niacin is then activated so it can form a steady bond with one end of the peptide. After purification the final powder is ready to dissolve into water based formulas.

You will mainly see Nicotinoyl Sh-Pentapeptide-4 in brightening serums, anti-aging creams, sheet masks, spot treatments and lightweight daily moisturizers where brands want a mix of tone improvement and hydration without strong acids or retinoids.

Nicotinoyl Sh-Pentapeptide-4’s Cosmetic Benefits/Uses

This multi-tasker supports several parts of a skin care routine

  • Bleaching: Helps fade the look of dark spots and uneven patches by slowing extra pigment production for a more uniform tone
  • Humectant: Draws water into the upper skin layers so the surface feels soft and looks plumper which can smooth fine lines
  • Skin Conditioning: Supports a healthy feel by boosting moisture balance and giving skin a silky aftertouch
  • Skin Protecting: Reinforces the skin barrier and offers antioxidant support from niacin, guarding against daily stress like pollution and light dryness

Who Can Use Nicotinoyl Sh-Pentapeptide-4

Nicotinoyl Sh-Pentapeptide-4 is gentle enough for most skin types. Dry or mature complexions appreciate its water-binding action while oily and combination skin benefit from the lightweight feel that will not clog pores. Sensitive skin generally tolerates it well because it lacks harsh acids or fragrances. Those with a known allergy to niacin or peptides, however, should steer clear since irritation could follow.

The molecule is produced entirely in the lab without animal by-products so it fits vegan and vegetarian lifestyles.

No specific warnings exist for pregnant or breastfeeding women when this ingredient is used on intact skin, yet personal circumstances differ. This information is not medical advice and anyone who is expecting or nursing should show the full product list to a qualified health professional before use.

Nicotinoyl Sh-Pentapeptide-4 does not make skin more sensitive to sunlight, though daily sunscreen is still encouraged to protect the brightening gains it delivers.

Potential Side Effects/Adverse Reactions

Responses to topical Nicotinoyl Sh-Pentapeptide-4 differ from one person to another. The items below are possible yet uncommon when the ingredient is included at safe levels in well-formulated products.

  • Temporary warmth or flushing
  • Mild redness or stinging, especially on very sensitive skin
  • Localized itching
  • Dry patches if overused alongside strong exfoliants
  • Allergic contact dermatitis in individuals allergic to niacin or specific peptides

If any of these reactions appear, discontinue use and seek guidance from a healthcare or skincare professional.

Comedogenic Rating

Rating: 0 / 5 – Non-comedogenic

Nicotinoyl Sh-Pentapeptide-4 is a water-soluble peptide-vitamin blend that leaves no oily film on the skin. It does not contain heavy waxes or butters that can block pores and its tiny molecular size is quickly absorbed or rinsed away. For these reasons it earns the lowest score on the comedogenic scale.

Because it has virtually no pore-clogging potential this ingredient is considered suitable for skin that is prone to acne or breakouts.

As a peptide attached to niacin it can be paired with most lightweight gels or lotions without raising the overall comedogenic profile of the finished product.

Summary

Nicotinoyl Sh-Pentapeptide-4 targets dark spots hydrates the surface layers conditions the skin feel and reinforces the barrier. It does this by combining the brightening power of niacin with a pentapeptide that pulls in water and signals skin to hold on to moisture while offering mild antioxidant support.

The ingredient is still a niche choice compared with big names like vitamin C or retinol yet it is gaining ground in modern serums masks and daily creams thanks to its multitasking benefits and gentle nature.

Overall safety data show a low risk of irritation for most users when formulas stay within recommended levels. Still everyone’s skin is different so it is smart to patch test any new product that lists Nicotinoyl Sh-Pentapeptide-4 before using it on the entire face.

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