What Is Nicotinoyl Tripeptide-35?
Nicotinoyl Tripeptide-35 is a lab-crafted molecule made by joining niacin, a form of vitamin B3, with a short chain of three amino acids. The result is a small peptide that carries the skin-friendly traits of both its parent parts. First introduced in the early 2010s, it emerged from research into peptides that can mimic or boost the skin’s own defense systems. Manufacturers create it through a controlled reaction where niacin chemically bonds to a pre-built tripeptide under specific temperature and pH settings. After purification the ingredient appears as a fine powder that dissolves well in water-based formulas.
You will most often spot Nicotinoyl Tripeptide-35 in leave-on products designed to protect and renew the skin. Common examples include anti-aging serums, daily moisturizers, brightening creams, lightweight lotions and sheet masks. Because it is water-soluble it blends smoothly into gel textures, emulsions and even some eye treatments where a non-greasy feel is important.
Nicotinoyl Tripeptide-35’s Cosmetic Benefits/Uses
This peptide serves mainly as an antioxidant. By neutralizing free radicals it helps shield the skin from environmental stressors such as UV light and pollution. Regular use can support a smoother, brighter look, and may slow the appearance of fine lines that arise when oxidative damage breaks down collagen and elastin. When included in a formula it also helps keep other sensitive ingredients stable, which can extend the overall shelf life of the product.
Who Can Use Nicotinoyl Tripeptide-35
Nicotinoyl Tripeptide-35 is gentle enough for most skin types including dry, normal, combination and oily. Its water based nature means it will not clog pores, which makes it a solid choice for those prone to breakouts. People with very reactive or allergy-prone skin should still proceed carefully because any peptide can trigger sensitivity in rare cases.
The ingredient is made through a laboratory process that does not rely on animal material, so it is generally considered suitable for vegans and vegetarians. As always, check the full product label because other components in the formula or the finished product’s testing policy could differ from brand to brand.
No research points to harmful effects on pregnant or breastfeeding women when used in typical cosmetic concentrations. That said, this is not medical advice and anyone who is pregnant or nursing should run all skincare choices past a qualified doctor before use just to be on the safe side.
Nicotinoyl Tripeptide-35 is not known to cause photosensitivity, and it plays well with sunscreen actives. Daily sun protection is still important to guard the skin from UV damage in general.
Potential Side Effects/Adverse Reactions
Responses to topical Nicotinoyl Tripeptide-35 vary from person to person. The issues listed below are possible but unlikely for most users when the ingredient is used at standard cosmetic levels.
- Temporary redness or mild stinging
- Warmth or flushing, especially on very fair or sensitive skin
- Localized itching or dryness
- Allergic contact dermatitis presenting as a rash or swelling
- Increased irritation if layered with strong exfoliating acids or retinoids
If you notice any of these reactions stop using the product and consult a healthcare professional or dermatologist for guidance.
Comedogenic Rating
Rating: 0 / 5
Nicotinoyl Tripeptide-35 is fully water-soluble and contains no oily or waxy parts that could block pores. Its small peptide structure rinses cleanly from the skin and does not leave a residue that traps dead cells or sebum, so it earns a solid zero on the comedogenic scale. This means the ingredient itself is considered safe for people who are prone to acne or frequent breakouts.
Keep in mind that the finished product also contains other ingredients. If the formula is packed with heavy oils or butters, overall pore-clogging risk may rise even though the peptide on its own is non-comedogenic.
Summary
Nicotinoyl Tripeptide-35 is used mainly as an antioxidant that helps neutralize free radicals before they can weaken collagen and dull the complexion. By tying niacin to a short chain of amino acids, chemists created a molecule that not only defends against everyday stressors but also helps keep other delicate ingredients stable so the whole formula performs better for longer.
The peptide is still a niche player compared with giants like hyaluronic acid or vitamin C, yet its buzz is growing as brands look for fresh ways to protect skin without heaviness or irritation.
Current data shows the ingredient is gentle, vegan friendly and unlikely to cause harm for most users when applied in typical cosmetic amounts. As with any new skincare item, do a quick patch test first so you can spot rare sensitivities before applying to your full face.