Nictoflorin: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Nictoflorin?

Nictoflorin is the cosmetic name for kaempferol-3-O-β-D-rutinoside, a plant derived flavonoid glycoside naturally present in sources such as buckwheat blossoms, ginkgo biloba leaves and certain citrus peels. Chemically it combines the antioxidant flavonoid kaempferol with the sugar pair rutinose, giving it both water friendly and oil friendly parts that help it blend into skincare formulas.

The compound was first isolated by botanists studying the health promoting pigments found in edible plants. As research on flavonoids uncovered their ability to fend off free radicals, cosmetic chemists began exploring Nictoflorin for topical use in the late twentieth century. Today manufacturers typically obtain it by gently extracting plant material with food grade solvents, then filtering and concentrating the extract. Some laboratories also produce it through enzymatic conversion of kaempferol, allowing a consistent high purity ingredient.

Thanks to its stability and skin friendly profile, Nictoflorin now appears in face masks, anti aging serums, daily moisturizers, after sun lotions, calming creams and protective treatment essences where brands want a natural antioxidant boost.

Nictoflorin’s Cosmetic Benefits/Uses

Formulators turn to Nictoflorin for several key roles that support healthy looking skin.

  • Antioxidant – helps neutralize free radicals created by sunlight and pollution which can dull tone and speed up visible aging while also guarding the formula itself from oxidation
  • Emollient – provides a light conditioning feel that softens rough patches, decreases flaky appearance and makes skin feel smoother without heaviness
  • Skin Protecting – forms a gentle shield on the surface that reduces moisture loss and cushions skin against everyday environmental stressors, promoting a calmer more resilient complexion

Who Can Use Nictoflorin

Nictoflorin is generally well tolerated by most skin types including dry, oily, combination, sensitive and mature because it is light, non greasy and low in irritants. Its antioxidant action can even help soothe easily reactive complexions. Extremely allergy prone users who react to botanical extracts should still keep an eye on how their skin feels since the molecule is plant derived.

The ingredient is sourced from plants and can be made through enzyme conversion of plant compounds, so it fits vegan and vegetarian lifestyles as long as the finished product as a whole is free of animal derived additives or animal testing.

No human data has linked topical Nictoflorin to problems during pregnancy or breastfeeding. That said safety research is limited, so this information is not medical advice. Pregnant or nursing people should show any new skincare item to their doctor first just to be safe.

Nictoflorin does not make skin more prone to sunburn. In fact its antioxidant nature can give a minor extra layer of protection against daylight stress, though it is never a substitute for sunscreen.

Potential Side Effects/Adverse Reactions

Side effects from topical Nictoflorin differ from person to person. The points below describe potential reactions that are considered uncommon. When the ingredient is used correctly in a well formulated product most users experience none of these problems.

  • Mild redness or warmth on very sensitive skin
  • Temporary itching or tingling, especially on freshly exfoliated or broken skin
  • Contact allergy in individuals already allergic to plants rich in flavonoids such as buckwheat or ginkgo
  • Very light yellow staining on fabrics if a formula with high Nictoflorin concentration is not fully absorbed

If you notice any of the effects above stop using the product and seek guidance from a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 0 out of 5

Nictoflorin is a small flavonoid glycoside that dissolves well in water based phases and leaves only a whisper-light film on skin. It contains no heavy oils or waxes that can block pores, and there are no published cases of it causing congestion. Because of this it is generally considered non-comedogenic and is suitable for people who are prone to acne or breakouts.

The only time pore clogging could become an issue is if Nictoflorin is blended into a product rich in comedogenic butters or thick occlusives. In that case the overall formula, not the Nictoflorin itself, would be the culprit.

Summary

Nictoflorin delivers three main benefits: it scavenges free radicals to help keep skin looking even and youthful, it softens rough patches for a smoother feel, and it lays down a light protective veil that helps the skin barrier hold on to moisture. It does this through the natural antioxidant power of kaempferol, the mild conditioning effect of its sugar portion, and its ability to sit evenly on the surface without a greasy after-feel.

While not yet a household name, Nictoflorin is gaining quiet popularity in clean and plant focused formulas thanks to its solid science, gentle profile and versatility. Current evidence shows it is safe for most users with few reported side effects, but as with any new skincare ingredient it is wise to patch test before applying a full face product that contains it.

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