Nonyl Nonoxynol-150: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Nonyl Nonoxynol-150?

Nonyl Nonoxynol-150 is a synthetic ingredient made by linking about 150 units of ethylene oxide to a nonylphenol base. The result is a large molecule that has one end that attracts water and another that grabs onto oils. This split personality lets it mix things that normally do not blend, which is why it is valued in skin and hair care.

The compound traces its roots to the mid-20th century when chemists were looking for better surfactants for household cleaners. Over time formulators noticed its mildness compared with older detergents and began adapting it for personal care. Today it is made in large reactors where nonylphenol reacts with ethylene oxide gas under heat and pressure. Careful control of temperature and reaction time allows manufacturers to reach the average chain length of 150 units that gives this grade its specific performance profile.

You will usually spot Nonyl Nonoxynol-150 in products that need to lift away dirt without stripping the skin or hair, such as facial cleansers, body washes, shampoo, micellar waters, makeup removers and exfoliating masks. It can also help stabilize creamy lotions and serums by keeping oil and water phases from separating.

Nonyl Nonoxynol-150’s Cosmetic Benefits/Uses

Formulators count on this ingredient mainly for one job, yet that single role can improve many product types.

  • Cleansing: Its surfactant nature loosens and removes excess oil, makeup and everyday grime while rinsing off easily, leaving skin or hair feeling fresh and comfortable

Who Can Use Nonyl Nonoxynol-150

Because it is a mild nonionic surfactant, Nonyl Nonoxynol-150 is generally well tolerated by most skin types, including normal, oily and combination skin. Dry or very sensitive skin may find frequent or high-level use slightly dehydrating since all surfactants can lift away natural lipids. Those with compromised or highly reactive skin barriers should look for formulas that balance the ingredient with soothing agents or use it less often.

The compound is synthetic and contains no animal-derived material, making it suitable for vegetarians and vegans as long as the finished product is certified cruelty free.

Current safety assessments have not flagged this ingredient as a concern for pregnancy or breastfeeding when used topically at the low levels found in cosmetics. Still this is not medical advice and anyone who is pregnant or nursing should run any skincare product past a healthcare professional just to be safe.

Nonyl Nonoxynol-150 does not heighten skin sensitivity to sunlight and does not require special daytime precautions beyond regular sunscreen use.

No known interactions with other common cosmetic actives are reported and it performs well alongside acids, retinoids and botanical extracts.

Potential Side Effects/Adverse Reactions

Responses to topical Nonyl Nonoxynol-150 differ from person to person. The effects below are possible yet uncommon when the ingredient is used at appropriate cosmetic levels.

  • Mild skin irritation
  • Transient stinging on very delicate or broken skin
  • Dryness or tightness if used in high concentrations or without follow-up moisturization
  • Eye irritation if the cleanser accidentally gets into the eyes
  • Allergic contact dermatitis in individuals specifically sensitized to phenolic compounds

If any discomfort redness or itching develops discontinue use and consult a healthcare professional if symptoms persist.

Comedogenic Rating

Rating: 1/5. Nonyl Nonoxynol-150 is a large water-soluble surfactant that rinses off cleanly and does not form an oily film on the skin. Because it stays mostly on the surface during use then washes away, it is highly unlikely to clog pores. Trace amounts left behind are minimal and non-occlusive, which keeps the risk of blackheads or whiteheads low.

Suitable for acne-prone skin in most rinse-off cleansers and micellar waters.

The comedogenic potential rises only if the ingredient appears in a leave-on formula at unusually high levels, a practice that is rare in the market.

Summary

Nonyl Nonoxynol-150 works as a mild surfactant and emulsifier, lifting dirt oil and makeup while helping keep oil and water mixes stable. Its dual water-loving and oil-loving structure lets it surround grime, break it apart then wash it down the drain without stripping skin or hair.

Although effective, it is less well known than gentler alkyl glucosides or trendy amino acid cleansers, so you will mainly encounter it in established mass-market formulas rather than the latest indie launches.

Current safety reviews deem it low risk at the small percentages used in cosmetics. Still every skin is different so patch testing any new product containing Nonyl Nonoxynol-150 is a smart precaution.

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