Nylon-12/6/66 Copolymer: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Nylon-12/6/66 Copolymer?

Nylon-12/6/66 Copolymer is a synthetic polymer created by combining three building blocks: nylon-12, nylon-6 and nylon-66. Each segment comes from different chain lengths of amino acids and diacids. When blended they form a lightweight flexible plastic powder that disperses easily in creams and gels. The material traces its roots to the textile industry where nylon fibers were prized for toughness and smooth feel. Formulators later noticed that finely milled nylon powders could sit on skin without a heavy or greasy sensation, so by the late 1990s these powders began appearing in makeup and skin care to improve texture and wear.

Manufacturing starts with separate polymerization of the three nylons. The finished pellets are melted together in a controlled ratio then rapidly cooled and ground into microspheres. Particle size is carefully screened to ensure a silky glide on skin. Because the copolymer is inert and water resistant it shows up in a variety of topical products including loose and pressed powders, liquid foundations, primers, long-wear lipsticks, sunscreens, blurring creams and some matte moisturizers.

Nylon-12/6/66 Copolymer’s Cosmetic Benefits/Uses

This ingredient earns its place on an ingredient list thanks to its film forming action that brings several practical benefits.

As a film former, Nylon-12/6/66 Copolymer lays down an invisible breathable layer that helps pigments and active ingredients stay put longer. The film resists sweat and oil so makeup is less likely to crease or fade through the day. In skin care it can lock in moisture by reducing water loss at the surface which leaves skin feeling smoother. The microspheres also scatter light and fill in fine lines giving an instant soft-focus effect that makes pores and wrinkles look less noticeable.

Who Can Use Nylon-12/6/66 Copolymer

This polymer is generally suitable for all skin types, including oily, combination, normal and dry. Its weightless feel and oil absorbing nature make it especially helpful for oily or combination skin that battles midday shine. Sensitive skin usually tolerates it well because the powder is inert and fragrance free, though anyone with a known sensitivity to synthetic polymers should remain cautious.

Nylon-12/6/66 Copolymer is synthesized entirely from petrochemical sources with no animal derived inputs so it aligns with vegan and vegetarian preferences.

Current research shows no evidence that the ingredient penetrates deeply or affects hormones, so it is not restricted for pregnancy or breastfeeding. That said this is not medical advice and expectant or nursing mothers should review any product containing it with their healthcare provider before use to stay on the safe side.

The copolymer does not make skin more sensitive to sunlight and it will not interfere with sunscreen actives. It is also odorless and colorless so it rarely alters the fragrance or shade of finished formulas.

Potential Side Effects/Adverse Reactions

Reactions to topical Nylon-12/6/66 Copolymer vary from person to person. The issues listed below are possible yet unlikely when the ingredient is used correctly in a well formulated product.

  • Mild skin irritation – a small number of users may notice redness stinging or itching, usually due to individual sensitivity rather than the ingredient itself
  • Clogged pores – heavy use in very occlusive products could trap oil and debris in acne-prone skin leading to breakouts
  • Eye discomfort – loose powders that contain the copolymer might cause temporary irritation if particles enter the eyes
  • Allergic contact dermatitis – rare cases of allergy to synthetic polymers can lead to rash swelling or flaking

If any of these reactions occur stop using the product and consult a healthcare professional for guidance.

Comedogenic Rating

Rating: 1/5 (low risk)

Nylon-12/6/66 Copolymer particles stay on the surface and absorb excess oil instead of blocking pores. The thin breathable film they form allows sebum and sweat to escape so congestion is uncommon. The rating is not zero because formulas that pair the powder with heavy oils or waxes can still feel occlusive and may trouble extremely breakout-prone skin.

Most acne-prone users can safely use products containing this ingredient without seeing extra pimples.

Clumping risk is highest in thick balms where the polymer can pack tightly, which may lead to a heavier feel and potential pore blockage in sensitive individuals.

Summary

Nylon-12/6/66 Copolymer works as a film former that locks makeup in place, scatters light to blur lines, cuts shine and gently seals in moisture while remaining weightless. Its microspheres create a smooth, soft focus finish and improve wear time in everything from primers to sunscreens.

Though not a buzzword ingredient it appears in many long wear and mattifying formulas because it quietly does the job without fuss.

Safety assessments show a low chance of irritation or allergy so the copolymer is generally considered safe for topical use. Even so skin can be unpredictable so it is always wise to patch test a new product that lists Nylon-12/6/66 Copolymer before applying it more broadly.

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