What Is Octapeptide-22 R-Thermus Thermophilus Putative Esterase Hexapeptide-40?
Octapeptide-22 R-Thermus Thermophilus Putative Esterase Hexapeptide-40 is a lab designed fusion peptide that combines segments from three separate peptide chains: Octapeptide-22, a peptide inspired by natural skin signaling molecules; Hexapeptide-40, a six-amino-acid fragment often explored for its smoothing properties; and a putative esterase sequence from the heat-loving bacterium Thermus thermophilus. Scientists stitched the corresponding genes together digitally, then inserted the synthetic gene into a food-grade strain of E. coli. Inside the bacterium the 329-amino-acid chain is produced through fermentation, harvested, purified and standardized for cosmetic use.
The ingredient’s journey into skincare began within biotech research aimed at mimicking the resilience of extremophile proteins. Developers noticed that certain fragments appeared to support skin barrier comfort, leading formulators to test them in topical prototypes. Because it is fully recombinant and not animal-derived, the material aligns with vegan and cruelty-free positions popular in modern beauty.
Today you will usually find Octapeptide-22 R-Thermus Thermophilus Putative Esterase Hexapeptide-40 in lightweight anti-aging serums, moisturizing creams, sheet masks and eye treatments that promise smoother texture or improved suppleness. It is often paired with humectants like glycerin or hyaluronic acid to enhance overall skin feel.
Octapeptide-22 R-Thermus Thermophilus Putative Esterase Hexapeptide-40’s Cosmetic Benefits/Uses
This ingredient is classified as a skin-conditioning agent, a broad term that covers compounds designed to maintain or improve the appearance and feel of skin.
As a skin-conditioning peptide it can support a softer touch, help the surface hold moisture longer and lend a temporarily plumped look that makes fine lines less noticeable. When used consistently it may contribute to a smoother overall complexion, giving formulas a premium performance edge without adding heaviness or greasy residue.
Who Can Use Octapeptide-22 R-Thermus Thermophilus Putative Esterase Hexapeptide-40
This peptide is lightweight, water soluble and non occlusive, which makes it generally well suited for dry, normal, combination and oily skin alike. Because it is fragrance free and carries a very low irritation profile, most sensitive skin users can also tolerate it, though anyone with a history of reactivity to fermented or biotech ingredients should be cautious.
The material is produced through bacterial fermentation with no animal derived substrates, so it aligns with vegan and vegetarian lifestyles.
No human data point to risks for pregnant or breastfeeding users when the peptide is applied topically at cosmetic strengths. That said, research on this exact fusion peptide is limited, so this text is not medical advice. If you are expecting or nursing, check with your physician before adding any new skincare product.
Unlike exfoliating acids or retinoids, this ingredient does not increase photosensitivity. Standard daytime sun protection is still encouraged, but no extra UV precautions are required specifically because of this peptide.
Potential Side Effects/Adverse Reactions
Responses to any skincare ingredient can differ from one person to the next. The points below outline potential, though uncommon, reactions a small percentage of users may encounter when Octapeptide-22 R-Thermus Thermophilus Putative Esterase Hexapeptide-40 is applied topically. When the finished product is properly formulated most people will not notice any negatives.
- Mild redness or warmth shortly after application
- Temporary itching or tingling, especially on very sensitive skin
- Localized dryness if the formula lacks adequate humectants or emollients
- Rare allergic contact dermatitis presenting as persistent rash or swelling
- Eye irritation if the product migrates too close to the lash line
If you experience any persistent discomfort or visible reaction stop using the product and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0
Octapeptide-22 R-Thermus Thermophilus Putative Esterase Hexapeptide-40 is a large, water soluble peptide with no known ability to clog pores or form an occlusive film. It lacks fatty acids, waxes or heavy oils that typically drive comedogenicity, so it receives the lowest rating on the scale.
Suitable for acne-prone and breakout-prone skin.
Because the ingredient is usually delivered in lightweight serums or gels it is unlikely to trap sebum or debris, further reducing blemish risk.
Summary
Octapeptide-22 R-Thermus Thermophilus Putative Esterase Hexapeptide-40 is a lab crafted fusion peptide that conditions skin, helping it feel softer, hold moisture longer and look a bit plumper which can blur fine lines. It does this by sitting on the surface in a water based matrix, attracting and binding hydration to give a smoother touch without heaviness.
The peptide is still a niche addition in skincare so you will mainly spot it in select anti aging serums or premium moisturizers rather than on every store shelf. Early adopters appreciate its vegan biotech story and gentle profile.
Current data show a very low irritation or sensitization risk and no pore clogging potential, making it safe for most skin types. Still, everyone’s skin is unique so try a small patch test whenever you introduce a product that features this peptide just to be safe.