Octoxynol-5: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Octoxynol-5?

Octoxynol-5 is a lab made ingredient that belongs to the family of nonionic surfactants called alkylphenol ethoxylates. Chemically it starts with p-tert-octylphenol, a synthetic compound related to phenol, which is then reacted with ethylene oxide an average of five times. This short chain of ethylene oxide units gives the finished molecule a water loving end and an oil loving end, allowing it to mix substances that normally separate.

The first versions of alkylphenol ethoxylates appeared in the 1940s when chemists searched for gentler alternatives to soap. Over time formulators noticed that shorter ethoxylate chains like Octoxynol-5 offered mild cleansing while remaining easy to rinse, so the ingredient found its way into personal care products during the 1960s and 1970s. It is still produced by controlled batch or continuous reactions where temperature and pressure are carefully managed to add the desired number of ethylene oxide units, followed by purification and quality checks.

Today Octoxynol-5 shows up in facial cleansers, micellar waters, makeup removers, shampoos, bubble baths, body washes, exfoliating scrubs, sheet masks and even some lightweight lotions or serums where a little extra solubilizing power is needed.

Octoxynol-5’s Cosmetic Benefits/Uses

In formulas designed for skin and hair care Octoxynol-5 plays two key roles:

  • Cleansing – Lifts away oil, dirt and makeup by surrounding them in tiny droplets that rinse off with water, helping products leave the skin or hair feeling fresh and non greasy
  • Emulsifying – Keeps water and oil based ingredients evenly blended so creams, lotions and washes stay smooth stable and pleasant to use

Who Can Use Octoxynol-5

Thanks to its mild nonionic nature Octoxynol-5 suits most skin types including normal, oily and combination. Dry or very sensitive skin can normally tolerate it in rinse-off products but leave-on formulas with higher levels may cause tightness so a gentler alternative might be preferred for those who are highly reactive.

The ingredient is synthesized in the lab from petrochemical feedstocks and contains no animal derived substances so it is appropriate for vegans and vegetarians.

Current safety data do not flag Octoxynol-5 as a concern for pregnancy or breastfeeding when used at the low levels found in cosmetics. Nonetheless this is not medical advice and anyone who is pregnant or nursing should review any skincare product with a qualified healthcare professional before adding it to a routine.

Octoxynol-5 does not increase photosensitivity and can be used in daytime formulas without raising the risk of sunburn, though wearing daily sunscreen is still important for overall skin health.

Potential Side Effects/Adverse Reactions

Responses to topical Octoxynol-5 can differ from person to person. The points below outline potential side effects that may occur, though most users will not experience them when the ingredient is formulated and used correctly.

  • Skin irritation – tingling, burning or redness, most often on very sensitive or compromised skin
  • Dryness – a tight or flaky feeling if the cleanser is left on too long or used too frequently
  • Allergic contact dermatitis – rare but possible rash or itching in those already sensitized to alkylphenol ethoxylates
  • Eye irritation – stinging and watering if a product accidentally gets into the eyes

If any of these effects occur stop using the product and consult a healthcare professional for guidance.

Comedogenic Rating

Rating: 0/5. Octoxynol-5 is a lightweight nonionic surfactant that is fully water soluble and leaves minimal residue after rinsing. It does not form heavy films that could clog pores, and it is not derived from fatty acids that sometimes cause breakouts. As a result it is considered non comedogenic and is generally suitable for people who are prone to acne or congestion.

Because most products containing Octoxynol-5 are wash off cleansers any tiny amount that might remain on the skin is unlikely to block follicles. Formulas that are left on the skin typically use very low levels, further lowering any pore clogging risk.

Summary

Octoxynol-5 works mainly as a cleanser and an emulsifier. Its structure gives it a water friendly end and an oil friendly end, letting it surround grime, makeup and excess sebum so they can be rinsed away and helping oil and water based ingredients stay evenly mixed for a smooth stable product.

While still used in many face washes and makeup removers it is not a headline ingredient and newer surfactants with greener profiles have taken some of its market share. Even so formulators appreciate its reliability, mildness and cost effectiveness which keeps it in circulation.

At the low concentrations allowed in cosmetics Octoxynol-5 is viewed as safe for most users when products are used as directed. As with any new skincare product it is wise to perform a small patch test first to rule out individual sensitivity.

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