What Is Oleoyl Tetrapeptide-31?
Oleoyl Tetrapeptide-31 is a lab crafted molecule that links a short chain of four amino acids, known as Tetrapeptide-31, with oleoyl chloride, a fatty acid derivative often sourced from olives. Joining the peptide to an oil-like tail helps the ingredient slip through the skin’s surface more easily so it can get to work where it is needed. Peptide research took off in the early 2000s when scientists learned that small protein fragments could signal skin to act younger; adding a lipid such as oleic acid was the next step to boost their delivery. Today manufacturers create Oleoyl Tetrapeptide-31 in controlled reactors that first build the peptide from individual amino acids, then attach the oleoyl group before purifying the final powder. You will most often spot it in age-defying serums, eye creams, rich moisturizers, overnight masks and targeted firming treatments.
Oleoyl Tetrapeptide-31’s Cosmetic Benefits/Uses
Formulators reach for this peptide because it offers two main perks that help skin look and feel its best.
- Antioxidant – helps neutralize free radicals generated by UV light and pollution which can otherwise lead to dullness and early wrinkles, keeping the complexion brighter and more even.
- Skin Conditioning – supports a smoother softer feel by reinforcing the skin barrier and encouraging a firmer appearance so fine lines look less pronounced.
Who Can Use Oleoyl Tetrapeptide-31
Most skin types can benefit from Oleoyl Tetrapeptide-31. Normal, dry and mature complexions often enjoy its firming and softening effect, while combination and oily skin usually tolerate it well because the molecule is used at very low concentrations that do not leave a greasy film. Extremely acne-prone users might prefer lightweight formulas to avoid pore congestion coming from richer accompanying ingredients rather than from the peptide itself.
The peptide is produced in a lab from amino acids and a fatty acid that can be sourced from plants, so it is generally considered suitable for vegans and vegetarians. Brands that certify their raw materials as non animal derived will note this on packaging.
No data links Oleoyl Tetrapeptide-31 with problems during pregnancy or breastfeeding. That said, this is not medical advice and anyone who is pregnant or nursing should have a quick word with their doctor before adding new skincare products.
The ingredient does not make skin more sensitive to sunlight and can be used morning or night. It also plays nicely with most common actives, including vitamin C and retinoids, so it is easy to slot into existing routines.
Potential Side Effects/Adverse Reactions
Reactions to Oleoyl Tetrapeptide-31 differ between individuals. The points below cover potential side effects, most of which are uncommon when the ingredient is properly formulated and applied to intact skin.
- Mild redness or warmth – temporary flushing can appear on very reactive skin when the product is first introduced
- Stinging around delicate eye tissue – may occur if a formula migrates into the eyes or if the area is already compromised
- Allergic contact dermatitis – rare but possible for those with a specific sensitivity to the peptide or other formula components
- Breakouts – more likely linked to heavy creams that contain the peptide rather than to the peptide itself, but blemish-prone users should stay alert
If any persistent irritation or other negative reaction develops stop using the product and consult a healthcare professional or dermatologist for guidance.
Comedogenic Rating
Oleoyl Tetrapeptide-31 scores a 1 out of 5 on the comedogenic scale. The peptide itself is used at tiny percentages and is water dispersible despite its fatty tail, so it is unlikely to sit in pores or create blockages. Any risk of congestion usually comes from heavier emollients or butters paired with it, not the peptide.
Because of this low rating it is generally considered suitable for acne-prone or breakout-prone skin, especially when found in lightweight serums or gels.
Formulas aimed at very dry or mature skin sometimes combine the peptide with rich oils that can push the overall product’s comedogenic potential higher. If clogged pores are a regular concern look for Oleoyl Tetrapeptide-31 in fluid or oil-free bases.
Summary
Oleoyl Tetrapeptide-31 delivers two standout benefits: it acts as an antioxidant that helps neutralize free radicals and it conditions skin by supporting a stronger barrier and a firmer feel. The peptide portion signals skin to behave in a more youthful way while the oleoyl tail improves penetration so the molecule can do its job efficiently.
You will mostly spot this ingredient in mid to high-end serums eye creams and overnight masks rather than drugstore basics making it a rising but still niche player in the peptide category.
Current data shows Oleoyl Tetrapeptide-31 is well tolerated for most skin types with only rare reports of irritation or allergy. Even so every skin is unique so it is wise to patch test any new product that contains this or any other active before applying it all over the face.