What Is Oligopeptide-105?
Oligopeptide-105 is a lab-made chain of 18 amino acids built from the skin-friendly building blocks alanine, glycine, proline and serine. Peptides like this started gaining attention in the 1990s when researchers saw that short strings of amino acids could tell skin cells to look and act younger. Modern solid-phase peptide synthesis lets chemists link the amino acids in a precise order then purify the result for cosmetic use. Because it is synthetic there is no animal or plant harvesting involved, which helps keep quality consistent from batch to batch.
Formulators add Oligopeptide-105 to products meant to smooth, hydrate and refresh the look of skin. You will most often spot it in lightweight serums, anti-aging creams, sheet masks, eye gels and leave-on moisturizers where it can stay on the skin long enough to do its job.
Oligopeptide-105’s Cosmetic Benefits/Uses
In skincare Oligopeptide-105 works primarily as a skin-conditioning agent, meaning it helps keep the surface soft, supple and comfortable. By supporting the skin’s own repair signals it can improve the look of texture and fine lines, boost moisture retention and give a healthier-looking glow over time.
Who Can Use Oligopeptide-105
Oligopeptide-105 is gentle enough for most skin types including dry, normal, combination and oily. Its lightweight texture and water-soluble profile mean it sits well on acne-prone or sensitive skin without clogging pores. There are no known reasons it would be unsuitable for any specific skin type, though extremely reactive skin should still introduce any new ingredient slowly.
Because the peptide is made entirely in the lab with no animal-derived components, it is considered suitable for vegans and vegetarians.
No data suggest a particular risk for pregnant or breastfeeding women when the peptide is applied topically, but this is not medical advice. Anyone who is expecting or nursing should have a quick chat with a doctor before adding new skincare just to be safe.
Oligopeptide-105 is not known to cause photosensitivity, so it can be used morning or night. Standard daily sunscreen is still recommended to protect skin health.
Potential Side Effects/Adverse Reactions
Side effects from topical Oligopeptide-105 differ from one person to the next. The issues listed below are only potential reactions and are unlikely for most users when the ingredient is formulated correctly.
- Temporary redness or warmth right after application
- Mild itching or stinging on very sensitive skin
- Localized rash or hives in people allergic to one of the formula’s other ingredients
- Rare breakout of small pimples if the product’s overall base is too rich for oily skin
If any discomfort or visible reaction occurs stop using the product and consult a healthcare professional.
Comedogenic Rating
Oligopeptide-105 scores a 0 on the comedogenic scale, meaning it is considered non-comedogenic. The molecule is water soluble, lightweight and does not leave an occlusive film that could trap oil or debris inside pores. Functionally it conditions skin without relying on heavy oils or waxes, so it is unlikely to trigger or worsen clogged pores.
This makes the ingredient generally suitable for people prone to acne or breakouts. When blemishes pop up after using a peptide product the culprit is usually richer emollients or fragrances in the overall formula rather than the peptide itself.
Because Oligopeptide-105 is used at low concentrations and rinses away easily with regular cleansing, build-up on the skin is minimal and long term pore blockage is improbable.
Summary
Oligopeptide-105 is a lab crafted 18-amino acid peptide that acts as a skin conditioning agent. By sending friendly repair signals to surface cells it helps skin hold moisture, look smoother and feel more resilient. The peptide does this without heavy oils, relying on its small size and similarity to the skin’s own proteins to support natural renewal.
While not yet as famous as hyaluronic acid or retinol, interest in targeted peptides keeps growing and Oligopeptide-105 is appearing in more serums and creams each year. Its vegan origin, low irritation profile and compatibility with most formulations make it attractive to brands looking for a modern conditioning ingredient.
Available research shows a very safe topical profile with no major red flags. Still, individual sensitivities vary so it is a good idea to patch test any new product containing Oligopeptide-105 before applying it to the entire face.