What Is Oligopeptide-107 Sh-Oligopeptide-1?
Oligopeptide-107 sh-Oligopeptide-1 is a lab-designed fusion peptide made to give skin the kind of support that naturally occurring growth factors provide. Chemically it is a single chain of 67 amino acids that links the sequences of two smaller peptides, sh-Oligopeptide-1 and Oligopeptide-107, into one streamlined molecule. The gene coding for this chain is stitched together in a DNA synthesizer then placed in a strain of E. coli. The bacteria act like tiny factories, fermenting the gene and producing large quantities of the peptide, which is later purified and blended into cosmetic formulas.
Peptide technology first caught the beauty industry’s eye in the early 2000s as brands searched for gentler alternatives to retinoids and acids. By fusing two well-researched peptides scientists created Oligopeptide-107 sh-Oligopeptide-1 to deliver broader skin benefits in a single ingredient. Today you will most often see it in anti-aging serums, sheet masks, eye creams, concentrated ampoules, daily moisturizers and post-treatment soothing gels where it helps the skin look smoother and more refreshed.
Oligopeptide-107 Sh-Oligopeptide-1’s Cosmetic Benefits/Uses
This peptide is valued for one main function in skincare formulas.
Skin conditioning: Oligopeptide-107 sh-Oligopeptide-1 supports the skin’s own renewal processes, encouraging a smoother surface and a more even tone. By signaling to skin cells to behave like younger versions of themselves it can improve the appearance of fine lines, boost softness and lend a healthy, well-hydrated look to the complexion.
Who Can Use Oligopeptide-107 Sh-Oligopeptide-1
This peptide is generally considered friendly for all skin types, including dry, oily, combination and sensitive skin. It is lightweight, non-greasy and does not add extra oil or clog pores, so even those prone to breakouts usually tolerate it well. If you have a known sensitivity to fermented or bio-engineered ingredients you may want to proceed with caution, but most people experience no issues.
The ingredient is produced through bacterial fermentation with no animal-derived materials, making it suitable for vegans and vegetarians.
Current data suggests the peptide poses no specific risk to pregnant or breastfeeding women when used on the skin. That said, research on expectant or nursing populations is limited. This information is not medical advice and anyone who is pregnant or nursing should ask a doctor before adding new skincare products, just to be on the safe side.
Oligopeptide-107 Sh-Oligopeptide-1 does not increase photosensitivity, so it will not make your skin more prone to sunburn. Daily sunscreen is still recommended as part of any good skincare routine.
The peptide layers well with common actives like niacinamide, hyaluronic acid, ceramides and gentle exfoliating acids. It has no known negative interactions with prescription topical treatments.
Potential Side Effects/Adverse Reactions
Reactions to topical Oligopeptide-107 Sh-Oligopeptide-1 vary from person to person. The effects listed below are only potential outcomes and are unlikely to occur for the typical user when the ingredient has been formulated and used correctly.
- Redness or mild stinging – usually short-lived and often linked to other ingredients in the formula rather than the peptide itself
- Itchiness – a small number of users may feel temporary itching as the skin adjusts
- Localized rash or hives – very rare and typically a sign of individual sensitivity to peptides or preservatives in the product
- Allergic contact dermatitis – an uncommon but more serious reaction involving persistent redness, swelling and discomfort that requires medical attention
If you develop ongoing irritation or any of the effects above stop using the product and consult a healthcare professional.
Comedogenic Rating
Rating: 0 out of 5
Oligopeptide-107 Sh-Oligopeptide-1 is a water-soluble peptide used at very low concentrations and contains no heavy oils, waxes or fatty acids that could block pores. Its large molecular size also keeps it on the skin surface rather than sinking into sebaceous follicles where breakouts start. For these reasons the ingredient itself is considered non-comedogenic.
Suitable for acne-prone or easily congested skin.
Keep in mind that the final product’s base matters more than the peptide when it comes to pore clogging. A lightweight serum or gel with this peptide will stay breakout-friendly while a rich butter-loaded cream might not, even though the peptide carries a zero rating.
Summary
Oligopeptide-107 Sh-Oligopeptide-1 is a lab-crafted 67-amino-acid fusion peptide that conditions skin by nudging cells to act younger, leading to smoother texture, softer feel and a more even tone. It accomplishes this by mimicking natural growth factor signals that support renewal and hydration.
While not yet a household name it is gaining traction in higher-end serums, masks and eye creams where brands look for gentle anti-aging boosters that play well with other actives.
The safety profile is reassuring: it is non-comedogenic, vegan, pregnancy-friendly and rarely triggers irritation when properly formulated. As with any new skincare step it is wise to patch test a product containing this peptide before full use just to be cautious.