What Is Oligopeptide-111?
Oligopeptide-111 is a lab-crafted chain of 11 amino acids built from familiar building blocks such as aspartic acid, lysine, leucine, asparagine, glutamine, arginine and serine. Because it is synthetic the peptide can be produced with precise purity and consistency, avoiding the variability that sometimes comes with natural extracts. The peptide first attracted attention in the early 2000s when formulators were searching for targeted molecules that could signal healthier looking skin without the heaviness of traditional oils. Manufacturing begins with solid-phase peptide synthesis, a step-by-step process that links amino acids in a fixed order, followed by purification to remove by-products. The finished ingredient is a fine powder that dissolves easily in water-based solutions, making it versatile for creams, serums, sheet masks, lightweight lotions and specialized anti-aging treatments focused on skin firmness and smoothness.
Oligopeptide-111’s Cosmetic Benefits/Uses
Formulators choose Oligopeptide-111 chiefly for its skin-conditioning ability. By helping skin hold onto moisture and supporting a smoother surface it can leave the complexion feeling softer and looking more even. Its small size allows it to sit comfortably in lightweight products so users get a conditioned finish without residue.
Who Can Use Oligopeptide-111
Because Oligopeptide-111 is lightweight and water-soluble it suits most skin types, including oily, dry, normal or combination skin. Sensitive skin generally tolerates the peptide well thanks to its low fragrance and low preservative requirements, though individuals with a history of reacting to peptides or complex formulas should proceed with caution.
The ingredient is produced entirely through synthetic manufacturing, with no animal-derived components or by-products, making it appropriate for both vegans and vegetarians.
No published data suggests that Oligopeptide-111 poses specific risks during pregnancy or while breastfeeding. Still, research on topical peptides in these groups is limited so this is not medical advice and anyone who is pregnant or nursing should speak with a healthcare professional before adding new skincare products.
Oligopeptide-111 does not increase photosensitivity and can be used in morning or evening routines without elevating the risk of sunburn. It is compatible with most common actives, including niacinamide and hyaluronic acid, and performs well across a broad pH range, which helps it fit into multi-step regimens.
Potential Side Effects/Adverse Reactions
Side effects from topical Oligopeptide-111 vary from person to person. The points below outline potential reactions only and most users will not experience them when the ingredient is formulated and used as directed.
- Mild redness or warmth at the application site
- Temporary itching or tingling
- Stinging if applied to broken or freshly exfoliated skin
- Rare allergic contact dermatitis presenting as swelling or rash
- Eye irritation if the product migrates into the ocular area
If any of these reactions occur stop using the product and seek guidance from a qualified healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Oligopeptide-111 is water-soluble, oil-free and used at very low concentrations, so it does not linger in pores or create an occlusive film that could trap sebum and debris. Its small molecular structure also rinses away easily during cleansing. For these reasons it earns a solid 0 and is considered suitable for people prone to acne or frequent breakouts.
Because the peptide is normally paired with lightweight gels or serums rather than heavy emollients, the finished formulas that feature it also tend to score low on the comedogenic scale. Always check the full ingredient list of the product, as carrier oils, silicones or butters—not the peptide itself—are more likely to influence clogging potential.
Summary
Oligopeptide-111 is a lab-made string of 11 amino acids that conditions skin by enhancing surface hydration and improving smoothness. Its compact size lets it blend seamlessly into water-based products, delivering a soft well-conditioned feel without weight or shine.
While not a household name like hyaluronic acid or retinol, it is quietly gaining traction in niche anti-aging and hydration-focused formulas because chemists value its stability and gentle profile.
Current data and user reports point to a strong safety record with minimal irritation risk, though any skincare ingredient can trigger sensitivity for some people. As with all new products, apply a small amount on a discreet patch of skin first to confirm personal tolerance before moving to full-face use.