What Is Oligopeptide-112?
Oligopeptide-112 is a lab made chain of 14 amino acids built from alanine, asparagine, arginine, aspartic acid, isoleucine, leucine, methionine, phenylalanine, threonine and valine. Because it is synthetic, it is free from animal or plant contaminants and its composition can be reproduced with high purity every time. Peptides started gaining traction in beauty products in the early 2000s when formulators noticed their ability to prompt skin friendly signals that could help maintain a youthful look. Oligopeptide-112 grew out of that research wave as chemists experimented with different amino acid sequences to create targeted benefits without irritation.
The ingredient is usually made with solid phase peptide synthesis, an automated step by step process that links each amino acid in the desired order. After building the chain, the raw material is cleaved from the resin, purified by filtration and chromatography then dried into a fine white powder ready for blending into cosmetic bases.
You will most often spot Oligopeptide-112 in lightweight serums, anti aging creams, sheet masks, concentrated ampoules, neck and décolletage treatments, eye area formulas, firming body lotions and after sun moisturizers where a conditioning boost is desired.
Oligopeptide-112’s Cosmetic Benefits/Uses
When worked into a topical formula, Oligopeptide-112 mainly acts as a skin conditioning agent, bringing several visible and sensory improvements.
As a skin conditioning ingredient, it helps the surface of the skin feel softer, smoother and more supple. By supporting a healthier moisture balance and reinforcing the skin’s own barrier, it can leave the complexion looking refreshed with a subtle plumped effect. Its small molecular size also means it can sit comfortably within most textures without weighing them down, allowing products to remain elegant while still delivering noticeable conditioning benefits.
Who Can Use Oligopeptide-112
Oligopeptide-112 is gentle enough for most skin types including normal, dry, combination and oily. Its lightweight feel suits people who dislike heavy creams while its conditioning action can still comfort drier complexions. Those with very sensitive or highly reactive skin can usually tolerate it because it carries no fragrance or known irritants, yet anyone with a history of peptide allergies should stay cautious.
The peptide is made entirely in the lab with no animal or plant matter so it is suitable for vegans and vegetarians. Because it is synthesized from basic building blocks rather than extracted from living tissues it avoids cross contamination concerns common with some animal derived proteins.
No data suggests that Oligopeptide-112 is unsafe for pregnant or breastfeeding women when used topically at the low levels found in cosmetics. Still this is not medical advice and anyone who is expecting or nursing should ask a healthcare professional before adding new products to their routine.
The ingredient does not make skin more prone to sunlight so there is no added photosensitivity. Standard daytime sunscreen use is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to any skincare ingredient can differ from person to person. The points below list potential side effects that could occur with topical Oligopeptide-112 though most users will not experience them when the product is made and used as directed.
- Mild redness or warmth shortly after application
- Temporary itching in very sensitive individuals
- Rare development of small bumps or rash if allergic to peptides
- Contact dermatitis when combined with other irritating actives in the same formula
If you notice any of the above or another unexpected reaction stop using the product and consult a medical professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Oligopeptide-112 is a water-soluble peptide that does not contain heavy oils, waxes or fatty acids known to block pores. Its small molecular size means it stays on or near the surface and is easily rinsed away during cleansing. For these reasons it is highly unlikely to clog pores or trigger blackheads and whiteheads. This makes it a safe choice for people who are prone to acne or breakouts.
Formulators often pair peptides with lightweight gel or serum bases, which further limits the chance of congestion. If the finished product also includes rich butters or occlusive silicones, overall pore-clogging potential will depend more on those companion ingredients than on Oligopeptide-112 itself.
Summary
Oligopeptide-112 is a lab-crafted chain of 14 amino acids that serves chiefly as a skin-conditioning agent. By supporting the skin’s moisture balance and reinforcing its surface barrier, it leaves the complexion feeling softer, smoother and subtly plumped. Its water-friendly structure lets it slip easily into light serums, eye creams and after-sun formulas without altering their texture.
While peptides in general have become buzzworthy since the early 2000s, Oligopeptide-112 is still something of a niche player compared with headline actives like retinol or niacinamide. You will most often find it in higher-end anti-aging or firming lines where formulators are looking for gentle yet effective support ingredients.
Safety data show low irritation potential, no photosensitivity and no links to systemic health concerns when used at cosmetic levels. As with any new skincare item it is smart to do a quick patch test before full-face use, especially if you have a history of allergies or very reactive skin.