What Is Oligopeptide-113?
Oligopeptide-113 is a lab-made chain of 23 amino acids that include familiar building blocks such as alanine, glycine, leucine, lysine, proline, serine, threonine, tryptophan, tyrosine and valine. Peptides like this one first caught the beauty industry’s eye in the early 2000s when research showed certain amino acid chains could signal skin cells to act younger. To create Oligopeptide-113, chemists usually rely on solid-phase peptide synthesis, a step-by-step method that links each amino acid in a specific order, then purifies the finished strand for safety and stability. Because it is made entirely in controlled lab conditions, it is consistent from batch to batch and free of animal-derived material. Brands most often add Oligopeptide-113 to anti-aging serums, firming creams, moisturizers, sheet masks and specialty eye treatments, where its skin-conditioning talent can shine.
Oligopeptide-113’s Cosmetic Benefits/Uses
Oligopeptide-113 is included in formulas for one main reason: skin conditioning. In practice, that means it helps soften the surface, improve suppleness, support a smoother feel and generally promote a healthier-looking complexion. By nurturing the skin’s outer layer, it can make other care steps work better and leave skin feeling refreshed and comfortable.
Who Can Use Oligopeptide-113
Oligopeptide-113 is considered friendly for most skin types including dry, combination and oily because it is lightweight and non occlusive. Sensitive and mature skin usually tolerate it well thanks to its gentle conditioning nature, although anyone with open wounds or an active infection should wait until the area has healed before applying products that contain it.
The peptide is synthesized in a lab with no animal derived materials, making it suitable for vegans and vegetarians. Manufacturers typically formulate it in water based solutions, so there is little risk of hidden animal by-products.
There are no known issues linked to topical use of Oligopeptide-113 during pregnancy or while breastfeeding. Still, this is not medical advice and pregnant or nursing individuals should clear any skincare routine with their doctor just to be safe.
Oligopeptide-113 does not increase photosensitivity, so it will not make skin more prone to sunburn. Standard daytime sun protection is still encouraged to guard against everyday UV damage. The ingredient also plays well with common actives such as hyaluronic acid, niacinamide and retinoids, so it can slot easily into most routines.
Potential Side Effects/Adverse Reactions
- Mild redness or flushing – uncommon and usually short lived
- Temporary itching or tingling – may occur on very sensitive skin
- Localized dryness – rare but possible if layered with multiple exfoliating actives
- Contact dermatitis – extremely rare allergic response marked by rash or swelling
If you notice any persistent or worsening reaction discontinue use and seek guidance from a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0/5 (non comedogenic)
Oligopeptide-113 is a water-soluble peptide that does not contain heavy oils, waxes or fatty acids known to clog pores. It sits lightly on the skin, is easily rinsed away and does not form an occlusive film, which is why formulators classify it as non comedogenic.
Because it carries a zero rating it is generally suitable for acne-prone or breakout-prone skin types. As always, the full product formula plays a larger role in pore clogging than a single ingredient, so check the rest of the label if congestion is a concern.
Summary
Oligopeptide-113 is a lab-made chain of 23 amino acids used in skincare for its skin-conditioning talent. By supporting the outer layer with moisture-binding amino acids it helps skin feel softer, look smoother and appear more resilient. This gentle action can enhance the performance of other actives layered on top.
The peptide is still relatively niche compared with big-name ingredients like hyaluronic acid or vitamin C, yet its presence is growing in high-performance serums and eye creams aimed at firmness and comfort.
Safety data show a very low risk of irritation or sensitization, making it a friendly addition for most routines. Even so, skin can be unpredictable so perform a quick patch test whenever introducing a new product that contains Oligopeptide-113.