What Is Oligopeptide-114 Acetate?
Oligopeptide-114 Acetate is a small-chain peptide that has been converted into its acetate salt to improve stability and compatibility with skin care formulas. The peptide itself is made up of a short series of amino acids, the tiny building blocks of proteins found naturally in the body. By adding acetic acid during production, chemists create a salt form that dissolves more easily in water-based products and resists early breakdown.
Peptides first gained popularity in beauty care in the late 1990s when researchers found that short protein fragments could help the skin look smoother and better hydrated. Since then, brands have explored many peptide variations. Oligopeptide-114 emerged from this wave of research as makers searched for multiuse ingredients that could both condition skin and fine-tune the feel of a formula.
The ingredient is produced in a lab through solid-phase peptide synthesis. Scientists link amino acids in a specific order on a resin, then release the finished chain and react it with acetic acid to form the acetate salt. The final powder is purified, dried and ready to be blended into cosmetic bases.
Because it offers both skin conditioning and oil-absorbing traits, Oligopeptide-114 Acetate shows up in lightweight moisturizers, daily serums, sheet masks, refreshing facial mists, oil-control primers and some anti-aging blends aimed at softening the look of fine lines.
Oligopeptide-114 Acetate’s Cosmetic Benefits/Uses
This peptide serves more than one role in a formula, making it handy for a wide range of products.
- Absorbent: Helps soak up excess sebum or surface moisture so the skin feels fresh not greasy. This can improve wear time of makeup and reduce midday shine
- Skin Conditioning: Supports a smooth soft feel after application, helping the skin hold on to water and feel comfortable throughout the day
Who Can Use Oligopeptide-114 Acetate
This ingredient is generally considered suitable for all skin types. Dry skin benefits from the light conditioning effect while oily or combination skin enjoys its ability to absorb excess sebum and cut down shine. Sensitive skin usually tolerates it well because peptides are non-acidic and tend to be gentle, though individuals with very reactive skin should still monitor how their skin feels.
Oligopeptide-114 Acetate is produced through laboratory synthesis using plant-derived or chemically created amino acids so it contains no animal material, making it appropriate for vegans and vegetarians. As always, check the full product label to confirm the entire formula aligns with personal ethics.
There is no evidence that this peptide poses particular risks for women who are pregnant or breastfeeding, but scientific data on expectant or nursing mothers is limited. This information is not medical advice and anyone who is pregnant or nursing should review new skincare products with a qualified healthcare provider before use.
The ingredient does not increase photosensitivity, meaning it will not make skin more prone to sunburn. Daily sunscreen is still important for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Oligopeptide-114 Acetate vary from person to person. The points below outline potential side effects, yet most people will not experience them when the ingredient is properly formulated and used as directed.
- Temporary redness or warmth
- Mild itching or tingling at the application site
- Dry or tight feeling if overused on very dehydrated skin
- Allergic contact dermatitis in rare cases for those sensitive to specific peptides or preservatives in the finished product
If any of these reactions occur stop using the product and seek advice from a healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Oligopeptide-114 Acetate is a small water-soluble peptide that does not leave an oily film or block pores. It is used at low levels, usually under 2 percent, and sits lightly on the skin. Because it absorbs excess sebum rather than adding it, the chance of clogging pores is minimal.
Suitable for acne-prone or breakout-prone skin.
Formulas that pair this peptide with heavy oils, waxes or butters could still trigger congestion, so scan the full ingredient list if you are highly sensitive.
Summary
Oligopeptide-114 Acetate conditions skin and soaks up extra surface oil. The short peptide chain binds water to keep skin soft while its absorbent nature helps reduce shine and improve makeup wear. It is not a headline ingredient yet brands that focus on lightweight hydration or oil control have started to include it.
Safety data shows a very low risk of irritation or pore blockage. Still, skin varies person to person so do a quick patch test when you try any new product that contains this peptide.