What Is Oligopeptide-117?
Oligopeptide-117 is a lab made chain of 12 amino acids that include alanine, glycine, histidine, isoleucine, lysine, phenylalanine, serine and threonine. Scientists created it to copy small protein fragments found naturally in skin that help keep it smooth and resilient. The peptide is produced through solid-phase peptide synthesis, a step-by-step method that links purified amino acids in a precise order, followed by purification and drying to form a stable white powder ready for cosmetic use. First explored in anti-aging research during the early 2000s, it gained popularity as brands looked for gentle yet effective alternatives to high strength actives. Today you will most often spot Oligopeptide-117 in serums, eye creams, moisturizers, sheet masks and targeted firming treatments where its role is to improve how skin feels and looks.
Oligopeptide-117’s Cosmetic Benefits/Uses
Its main job in a formula is skin conditioning, meaning it helps skin feel softer, smoother and more supple by supporting the surface proteins that keep skin flexible and hydrated.
Who Can Use Oligopeptide-117
Thanks to its gentle conditioning profile Oligopeptide-117 is generally suitable for all skin types, including dry, normal, combination, oily and sensitive skin. It has no known ingredients that would clog pores or trigger excess oil, so acne-prone users can usually enjoy it without worry.
The peptide is made entirely in a lab from individual amino acids and no animal-derived materials are used at any stage, so it is considered appropriate for vegans and vegetarians.
Current research shows no direct issues for pregnant or breastfeeding women when Oligopeptide-117 is applied topically in typical cosmetic concentrations. This is not medical advice so anyone who is expecting or nursing should still check with a qualified healthcare professional before adding a new product to their routine.
Oligopeptide-117 does not increase photosensitivity, meaning it will not make skin more prone to sunburn. Standard daily sunscreen use is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Oligopeptide-117 can differ from one person to another. The points below list potential side effects that have been reported, yet most users will not experience them when the ingredient is used correctly in a well-formulated product.
- Mild redness or warmth
- Transient itching
- Light stinging on very sensitive or compromised skin
- Allergic contact dermatitis in rare cases
If any worsening irritation or unexpected reaction occurs discontinue use and consult a healthcare professional.
Comedogenic Rating
Rating: 0 (non comedogenic). Oligopeptide-117 is a small water soluble molecule that does not leave an oily film or block pores. It is used in very low concentrations and typically sits within lightweight formulations that rinse or absorb easily. Because it lacks fatty acids and waxy carriers it poses virtually no risk of clogging follicles, making it a safe choice for people prone to acne or breakouts. There are no reports of peptide fragments increasing sebum production or exacerbating comedones.
Summary
Oligopeptide-117 is a lab crafted twelve-amino-acid peptide whose main role is skin conditioning. By mimicking fragments of the skin’s own support proteins it helps surface cells stay hydrated, smooth and resilient, leading to a softer feel and a fresher appearance. Though not as famous as retinol or vitamin C it has gained quiet popularity in modern serums, eye creams and sheet masks aimed at gentle firming and moisture support.
Safety data show a low irritation profile and no comedogenicity, making it suitable for nearly all skin types including sensitive and acne prone skin. As with any new skincare ingredient a small patch test is wise before full use to rule out personal sensitivities.