What Is Oligopeptide-118?
Oligopeptide-118 is a lab made chain of 12 amino acids that include arginine, glutamic acid, leucine, lysine, phenylalanine, threonine and tyrosine. Because it is created synthetically, there is no animal or plant source involved, which helps keep quality and purity consistent from batch to batch. Peptide researchers first explored it while looking for short amino acid sequences that could support a smoother, more resilient skin surface. Today manufacturers assemble the peptide through solid phase synthesis, a step-by-step process that links each amino acid in a controlled setting, then purifies and dries the finished ingredient into a fine powder ready for formulators.
You will most often see Oligopeptide-118 in leave-on products where close skin contact allows it to perform at its best. Common examples include face serums, lightweight moisturizers, sheet masks, targeted eye treatments and anti-aging creams. It may also appear in overnight sleeping packs or booster drops that aim to support skin softness and overall comfort.
Oligopeptide-118’s Cosmetic Benefits/Uses
Formulators reach for this peptide because it helps create a more hydrated, supple complexion.
Skin conditioning: Oligopeptide-118 can improve the feel and appearance of the skin surface, helping it look smoother and better moisturized which in turn supports a fresh, healthy-looking finish.
Who Can Use Oligopeptide-118
Because this peptide is gentle and non-occlusive, it can suit dry, normal, combination and oily skin alike. Those with very sensitive or easily irritated skin usually tolerate it well since it lacks common triggers such as fragrance or essential oils. Its lightweight nature also makes it a friendly option for acne-prone skin as it does not clog pores or leave a heavy residue.
Oligopeptide-118 is synthesized entirely in the lab with no animal-derived components, so it aligns with vegan and vegetarian lifestyles.
Current research shows no specific concerns for pregnant or breastfeeding women when using Oligopeptide-118 in topical products. Still, this is not medical advice and anyone who is expecting or nursing should discuss all skincare choices with a qualified healthcare provider to be safe.
The ingredient does not increase photosensitivity, meaning it will not make skin more vulnerable to sunburn. Standard daytime sun protection is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Reactions to topical Oligopeptide-118 can vary from person to person. The points below list potential issues, though they are uncommon when the ingredient is properly formulated and used as directed.
- Mild redness or warmth at the application site
- Tingling or transient stinging on very sensitive skin
- Rare allergic contact dermatitis presenting as itching or small bumps
- Interaction with highly acidic or exfoliating products leading to temporary discomfort
If any irritation or unexpected reaction occurs users should discontinue use and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0 out of 5. Oligopeptide-118 is a small water soluble molecule that does not form an oily film or sit heavily on the skin, so it has no tendency to block pores. It lacks waxes, butters or long-chain fatty acids that typically raise comedogenicity scores.
Because of this low rating it is considered suitable for people who are prone to acne or frequent breakouts.
Keep in mind that the finished product formula still matters; if the peptide is blended into a rich, occlusive base the overall pore-clogging potential could change.
Summary
Oligopeptide-118 is used mainly as a skin-conditioning agent that helps the surface feel softer, smoother and better hydrated. Its short chain of amino acids can encourage a more resilient moisture barrier and support a fresh, supple look.
While not yet a household name it is gaining quiet popularity among formulators who want lightweight, vegan friendly peptides that play well with most skin types.
Current data shows it is low risk for irritation, non-photosensitising and appropriate for everyday use. As with any new skincare ingredient it is wise to do a quick patch test when trying a product that contains Oligopeptide-118 to make sure your skin agrees with it.