What Is Oligopeptide-131?
Oligopeptide-131 is a laboratory-made chain of 11 amino acids that include cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, phenylalanine, serine and tyrosine. Because it is synthetic, manufacturers can control its purity and stability more easily than naturally sourced proteins. Interest in short peptides for skin care took off in the early 2000s when researchers discovered that specific sequences could signal skin cells to behave in a more youthful way. Oligopeptide-131 emerged from this wave of innovation as chemists fine-tuned peptide lengths to balance efficacy with ease of formulation.
The ingredient is produced through solid-phase peptide synthesis, a stepwise method that adds one protected amino acid at a time to a growing chain anchored on a resin bead. After the sequence is complete, the peptide is cleaved from the resin, purified and lyophilized into a stable powder that dissolves easily in water-based or hydro-alcoholic systems.
Thanks to its flexibility, Oligopeptide-131 appears in a wide range of topical products. You will most often find it in anti-aging serums, firming creams, sheet masks, eye gels, post-procedure soothing formulas and high-performance moisturizers that aim to improve overall skin texture.
Oligopeptide-131’s Cosmetic Benefits/Uses
Formulators include Oligopeptide-131 to improve how the skin looks and feels once a product has been applied.
Its sole function is skin conditioning, meaning it helps soften and smooth the surface, supports a healthier-looking barrier and can enhance the feeling of suppleness over time.
Who Can Use Oligopeptide-131
Oligopeptide-131 is gentle and lightweight so it suits most skin types including dry, oily, combination and sensitive skin. Because it is water-soluble and non-occlusive it does not typically aggravate acne and it will not leave a heavy film on oil-prone complexions.
The peptide is made entirely through synthetic chemistry without animal-derived materials which makes it appropriate for vegans and vegetarians provided the rest of the finished formula aligns with cruelty-free standards.
No specific data links Oligopeptide-131 to risks during pregnancy or breastfeeding, yet safety studies on expectant and nursing mothers are limited. This content is for information only and not medical advice so anyone who is pregnant or nursing should show the full ingredient list to a healthcare professional before use.
The ingredient does not cause photosensitivity and it plays well with sunscreen filters and most common actives such as retinol glycolic acid and vitamin C. It is also fragrance-free by itself which lowers the chance of scent-related irritation.
Potential Side Effects/Adverse Reactions
Side effects from topical Oligopeptide-131 vary from person to person. The following are potential reactions that may occur in rare cases. When the ingredient is formulated and used correctly most people will not experience any of these issues.
- Mild redness or flushing during the first few uses
- Transient stinging or warmth on very sensitive skin
- Localized itching that resolves after rinsing
- Allergic contact dermatitis if an individual is sensitized to one of the peptide’s amino acids or a co-ingredient in the formula
- Increased irritation if layered immediately after strong exfoliants or prescription treatments
If any persistent or worsening reaction occurs discontinue use and consult a healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Oligopeptide-131 is a small, water-soluble peptide that sinks into the skin without leaving behind heavy oils or waxes that can clog pores. It does not form an occlusive film and has no fatty acid tails, both of which are common culprits in pore blockage. For these reasons formulators consider it non-comedogenic and it is generally safe for people who are prone to acne or breakouts.
Any risk of congestion will come from the overall product recipe, not the peptide itself, so check the full ingredient list if your skin is very reactive.
Summary
Oligopeptide-131 is used to condition the skin, helping it feel smoother, softer and better hydrated. It achieves this by acting as a signal molecule that encourages skin cells to support a healthy surface while also binding a light layer of moisture.
Although it is not one of the most famous peptides on the market it appears in a growing number of niche anti-aging serums, soothing gels and post-procedure lotions thanks to its gentle profile and ease of formulation.
Current data shows the ingredient is well tolerated with very low risk of irritation or pore clogging for most users. As with any new skincare product it is smart to perform a quick patch test before full application, especially if your skin is sensitive.