What Is Oligopeptide-136?
Oligopeptide-136 is a lab-made chain of 12 amino acids that include alanine, asparagine, arginine, cysteine, glycine, leucine, proline and serine. Because it is created by chemists rather than taken from animals or plants it is considered a synthetic peptide. Its balanced mix of small amino acids helps it blend well with water-based formulas.
Peptides began gaining attention in skin care in the early 2000s when researchers discovered their role in signaling and skin repair. Oligopeptide-136 was developed during this wave of innovation as brands searched for short peptides that could condition skin without irritation. Today it is produced through solid-phase peptide synthesis, a step-by-step process where each amino acid is added in sequence, then the finished chain is purified to remove by-products.
You will most often see Oligopeptide-136 in lightweight serums, leave-on masks, daily moisturizers and targeted anti-aging treatments. Its water-soluble nature lets formulators add it to gels, lotions or sheet mask essences without changing texture or scent.
Oligopeptide-136’s Cosmetic Benefits/Uses
This ingredient serves one key role in skin care formulas: skin conditioning. By sitting on the surface and binding water it helps keep the outer layer soft smooth and flexible, which can make skin look healthier and feel more comfortable.
Who Can Use Oligopeptide-136
Because it is water soluble and lightweight Oligopeptide-136 suits most skin types including oily, combination, normal and dry skin. Its gentle nature also makes it a good choice for sensitive skin since it does not contain fragrance or known irritants. Extremely reactive or allergy-prone skin should still proceed cautiously as with any new cosmetic ingredient but there is no clear evidence that this peptide is unsuitable for any specific skin type.
The peptide is entirely synthetic and contains no animal derived materials so it aligns with vegan and vegetarian preferences. As with all cruelty-free claims consumers should also verify the finished product’s animal testing status with the brand.
No studies have flagged Oligopeptide-136 as unsafe for use during pregnancy or while breastfeeding. It stays on the surface of the skin and is unlikely to reach systemic circulation. That said this is not medical advice and anyone who is pregnant or nursing should check with a healthcare professional before adding new skin care products.
Oligopeptide-136 does not make skin more sensitive to sunlight and can be used morning or night. Daily sunscreen is still recommended to protect overall skin health.
Potential Side Effects/Adverse Reactions
Individual responses to topical ingredients differ so the points below describe potential rather than expected reactions. When used as directed in a well-formulated product most people will not experience problems.
- Transient redness or warmth – a short-lived flush may appear as skin adjusts to the peptide but usually settles quickly
- Mild itching or tingling – rare and generally linked to very sensitive skin
- Contact dermatitis – an allergic response is possible if someone is specifically sensitive to one of the amino acids or to other ingredients in the formula
- Breakouts – unlikely from the peptide itself yet heavy or occlusive base formulas that contain it could clog pores in acne-prone skin
If irritation swelling or any persistent discomfort occurs stop using the product and consult a medical professional.
Comedogenic Rating
Rating: 0 / 5
Oligopeptide-136 is fully water soluble, does not form a film that traps sebum, and has no oily or waxy components that could block pores. Current literature and formulation data show no link between this peptide and clogged follicles, so it earns a non comedogenic score of 0.
Suitable for acne prone or breakout prone skin.
Any chance of congestion would more likely stem from the overall product base rather than the peptide itself.
Summary
Oligopeptide-136 is a lab crafted 12 amino acid chain used mainly as a skin conditioning agent. By attracting and holding water at the surface it softens rough patches, boosts flexibility, and leaves skin feeling smoother.
While peptides as a group are popular talking points in skin care marketing, this specific peptide remains a niche choice seen in select serums, masks, and moisturizers aimed at gentle hydration.
Safety data shows a very low risk of irritation, allergy, or pore blockage making it a friendly option for most skin types including sensitive and acne prone skin. As with any new product a quick patch test is a smart step to be sure your skin agrees.