What Is Oligopeptide-137?
Oligopeptide-137 is a lab-created chain of 12 amino acids built from alanine, glutamic acid, glycine, leucine, phenylalanine, serine and threonine. Because it is synthetic, it does not come from animals or plants but is produced through solid-phase peptide synthesis, a step-by-step method that links purified amino acids in a specific order, followed by filtration and freeze-drying to yield a fine, water-soluble powder. Peptides began attracting attention in the skin care world in the early 2000s as gentle messengers that could support a smoother, more resilient complexion, and Oligopeptide-137 was added to ingredient lists once formulators noticed its ability to condition skin without heavy oils or waxes. Today it turns up in lightweight serums, anti-aging creams, sheet masks, post-procedure soothing gels, eye treatments and daily moisturizers where a satiny finish is desired.
Oligopeptide-137’s Cosmetic Benefits/Uses
This ingredient is valued for one main role in topical formulas
Skin conditioning: Oligopeptide-137 helps skin feel softer and look smoother by supporting surface hydration and reinforcing the natural barrier so moisture stays where it is needed. Regular use can improve overall texture, reduce the appearance of flakiness and leave the complexion looking fresh and supple.
Who Can Use Oligopeptide-137
Because Oligopeptide-137 is lightweight and free of pore-clogging oils it suits most skin types, including dry, oily, combination and sensitive skin. Those with very reactive skin may still appreciate its gentle nature since peptides are generally well tolerated, though anyone with a known allergy to any component in the finished formula should proceed with caution.
The peptide is produced entirely in a lab with no animal-derived materials so it is appropriate for vegans and vegetarians.
No research points to specific risks for women who are pregnant or breastfeeding when Oligopeptide-137 is used topically in standard cosmetic concentrations. This is not medical advice and anyone who is pregnant or nursing should discuss all skincare products with a healthcare professional to be safe.
Oligopeptide-137 does not cause photosensitivity. It can be paired with daily sunscreen and most common actives such as vitamin C, retinol and niacinamide without known conflicts.
Potential Side Effects/Adverse Reactions
Responses to topical Oligopeptide-137 vary from person to person. The effects listed below are only potential outcomes and are unlikely for the average user when the ingredient is properly formulated.
- Temporary redness or warmth – a mild flush that usually settles quickly
- Itching or tingling – often short lived and linked to overall product composition rather than the peptide itself
- Dry patches – rare and typically tied to overuse of other active ingredients in the same routine
- Allergic contact dermatitis – very uncommon but possible if you are sensitive to a preservative, fragrance or the peptide sequence
- Eye irritation – may occur if a product migrates into the eyes though this is generally minimal
If you experience any persistent discomfort stop using the product and consult a healthcare professional.
Comedogenic Rating
Rating: 0/5
Oligopeptide-137 is a small, water soluble peptide with no heavy oils, waxes or fatty acids so it does not linger on the pore lining or create an environment that traps sebum. Because it rinses cleanly during normal cleansing and is typically used at very low concentrations it earns the lowest possible comedogenic score.
Suitability for acne-prone skin: Excellent choice for those who experience breakouts or congestion.
Since the ingredient is often blended with other actives, always check the full formula for comedogenic additives such as rich plant butters or certain silicones that could offset the peptide’s non-clogging nature.
Summary
Oligopeptide-137 is a lab crafted 12-amino-acid peptide prized for its skin conditioning talent. It attracts and holds surface moisture then helps fortify the barrier so skin feels softer looks smoother and maintains a healthy glow. Lightweight and oil free it slides easily into serums creams eye gels and post-procedure products without leaving residue.
While not as famous as blockbuster peptides like palmitoyl pentapeptide-4 it has a quiet following among formulators who want gentle hydration with a silky finish. Its vegan origin and broad compatibility with other actives add to its appeal.
Current data show it is safe for topical use with minimal risk of irritation or clogged pores. As with any new skincare ingredient do a small patch test when trying a product that contains Oligopeptide-137 to confirm personal tolerance.