What Is Oligopeptide-145 Dimer?
Oligopeptide-145 Dimer is a small chain of amino acids formed when two identical Oligopeptide-145 molecules join through a sulfur-based bond called a disulfide bridge between their cysteine units. This link stabilizes the peptide and helps it stay active on the skin. Most cosmetic suppliers create the ingredient in the lab by solid-phase peptide synthesis, a precise process that strings amino acids together one by one then oxidizes the cysteines to build the bridge. Using a lab route keeps purity high and eliminates the need for animal or plant extraction.
Peptides began attracting attention in skin care in the late 1990s after studies showed they could signal cells to behave more youthfully. As research expanded, formulators started exploring different peptide sizes and pairings. The dimer form of Oligopeptide-145 emerged as a way to boost stability without enlarging the molecule too much, allowing it to penetrate the upper layers of the skin while remaining effective.
You will usually spot Oligopeptide-145 Dimer in targeted anti-aging serums, firming creams, sheet masks, post-procedure soothing gels and high-performance moisturizers. Brands add it to products meant to smooth texture and support overall skin vitality.
Oligopeptide-145 Dimer’s Cosmetic Benefits/Uses
Oligopeptide-145 Dimer plays a focused role in skin care formulas.
Skin conditioning: The peptide helps keep the skin surface soft supple and well hydrated. By supporting the skin’s natural protein network it can improve the look of firmness and reduce the appearance of fine lines giving the complexion a smoother healthier finish.
Who Can Use Oligopeptide-145 Dimer
Because it is lightweight and non greasy Oligopeptide-145 Dimer suits most skin types including dry oily combination and sensitive skin. It conditions without clogging pores so even acne-prone users can typically incorporate it without worry. The peptide is produced entirely through laboratory synthesis with no animal derived inputs so it is suitable for vegans and vegetarians.
There is no evidence that the ingredient interferes with pregnancy or lactation when used topically at the low percentages found in cosmetics. Still this is not medical advice and anyone who is pregnant or breastfeeding should discuss any new skin care product with a qualified health professional to be safe.
Oligopeptide-145 Dimer does not make the skin more reactive to sunlight and it has no known issues with daytime use. It also layers well with other common actives such as niacinamide hyaluronic acid and ceramides.
Potential Side Effects/Adverse Reactions
Side effects from topical Oligopeptide-145 Dimer can vary from person to person. The following list covers potential reactions yet most users will not experience them when the ingredient is formulated correctly and applied as directed.
- Temporary redness – mild flushing that usually subsides quickly
- Stinging or itching – brief discomfort that may occur on very sensitive skin
- Dry patches – rare tightness if the formula lacks adequate moisturizers
- Allergic contact dermatitis – uncommon rash or swelling due to individual sensitivity to the peptide or other formula components
- Increased irritation when layered with strong exfoliants or retinoids – using multiple actives simultaneously can sometimes overwhelm the skin barrier
If any of these effects appear stop using the product and consult a healthcare professional if symptoms persist or worsen.
Comedogenic Rating
Rating: 0 (non-comedogenic). Oligopeptide-145 Dimer is a small, water-compatible molecule used at very low percentages, so it does not form an occlusive film or trap oil in pores. Its job is to condition skin rather than add heavy emollience, which keeps pore-clogging potential minimal.
This makes the peptide suitable for people prone to acne or breakouts. As with any ingredient, the overall formula matters; if the product pairs the peptide with rich butters or heavy oils the final comedogenicity could rise.
Summary
Oligopeptide-145 Dimer is mainly a skin-conditioning peptide that helps skin feel smoother, look firmer and stay comfortably hydrated by supporting the protein network at the surface. It is still a specialty ingredient found in targeted serums, masks and high-performance moisturizers rather than in basic cleansers or lotions, but its presence is growing as brands seek sophisticated yet gentle actives.
Current research and consumer feedback point to a high safety profile with low irritation risk. Even so, individual sensitivity varies, so performing a quick patch test when trying a new product containing the peptide is a smart habit.