What Is Oligopeptide-174 Sh-Pentapeptide-4 Sp?
Oligopeptide-174 Sh-Pentapeptide-4 Sp is a lab made fusion of two short chains of amino acids, Oligopeptide-174 and sh-Pentapeptide-4. Together they form a 20-amino-acid sequence that can include tiny bridges called disulfide bonds and sugar attachments known as glycosylation. Because it is created from the same 20 standard amino acids found in our skin and body it is classed as a biomimetic or skin friendly peptide.
Peptides began showing up in cosmetics in the late 1980s when researchers discovered that short amino acid chains could “talk” to skin cells. Over time scientists started blending different peptides to get a wider range of benefits. Oligopeptide-174 Sh-Pentapeptide-4 Sp is one of these newer blends, designed to bring antioxidant activity together with skin conditioning and emollient properties in a single ingredient.
The ingredient is produced through solid-phase peptide synthesis, a step by step process where each amino acid is added in a set order while the chain is anchored to a solid resin. After the full sequence is in place the peptide is detached, purified, and may undergo gentle chemical steps to form disulfide bridges or add sugars. Finally it is filtered and freeze-dried into a stable powder ready to be mixed into cosmetic formulas.
You will most often see Oligopeptide-174 Sh-Pentapeptide-4 Sp in leave-on products such as anti aging serums, eye creams, moisturizers, sheet masks, after-sun gels and targeted treatment ampoules. Formulators like it because it dissolves easily in water based phases and remains effective at the low concentrations typical for peptides.
Oligopeptide-174 Sh-Pentapeptide-4 Sp’s Cosmetic Benefits/Uses
This multitasking peptide adds several useful qualities to a skincare formula
- Antioxidant: Helps neutralize free radicals created by UV light and pollution which can otherwise lead to dullness and premature lines
- Skin Conditioning: Supports a smoother softer feel by encouraging skin’s own repair signals and helping maintain a healthy surface barrier
- Emollient: Offers a light cushioning effect that can make a product feel silkier while reducing transepidermal water loss for better hydration
Who Can Use Oligopeptide-174 Sh-Pentapeptide-4 Sp
This peptide is considered friendly for most skin types. Because it is lightweight and water soluble it suits oily, dry, combination and sensitive skin without clogging pores or leaving a greasy feel. People with known allergies to peptides or preservatives used alongside them should proceed with caution.
The ingredient is made entirely by chemical synthesis with no animal sourced materials so it is suitable for vegans and vegetarians.
Current research shows no specific risks for women who are pregnant or breastfeeding. The molecule is large and stays on the surface so systemic absorption is unlikely. That said this is not medical advice and anyone who is expecting or nursing should show the full ingredient list of any product to a qualified doctor before use just to be safe.
Oligopeptide-174 Sh-Pentapeptide-4 Sp does not cause photosensitivity. Normal daytime sun protection is still recommended to guard against UV damage.
Potential Side Effects/Adverse Reactions
Responses to topical Oligopeptide-174 Sh-Pentapeptide-4 Sp differ from person to person. The points below cover potential issues that could occur although they are uncommon when the ingredient is used at the low levels typical in cosmetics.
- Transient redness or warmth right after application
- Mild stinging or itching on very reactive skin
- Rare allergic contact dermatitis presenting as rash or swelling
- Pilling when layered with heavy silicone primers or high mineral SPF formulas
If any of these reactions appear stop using the product and seek advice from a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0/5. Oligopeptide-174 Sh-Pentapeptide-4 Sp is a small, water-soluble peptide that does not contain heavy oils or waxes that might block pores. It stays on the skin surface, absorbs quickly and is used at very low concentrations, all of which keep its clogging potential virtually nil.
This makes it a safe choice for people who are prone to acne or frequent breakouts.
No data suggest the peptide interacts with sebum or alters oil flow, so its non-comedogenic status should remain consistent across different formulations, provided the rest of the product is also low in pore-clogging ingredients.
Summary
Oligopeptide-174 Sh-Pentapeptide-4 Sp acts as an antioxidant, skin conditioner and light emollient. It neutralizes free radicals, signals skin to refresh its surface proteins and forms a thin moisturizing film that slows water loss, all while staying lightweight and residue-free.
The peptide is still a niche addition compared with bigger names like niacinamide or retinol, yet formulators appreciate its multitasking profile which is gradually boosting its presence in serums, eye creams and sheet masks.
Current evidence shows it is well tolerated for most skin types with minimal risk of irritation or pore clogging. As with any new cosmetic ingredient it is wise to perform a quick patch test when trying a product containing Oligopeptide-174 Sh-Pentapeptide-4 Sp to confirm personal compatibility.