What Is Oligopeptide-175?
Oligopeptide-175 is a lab-crafted peptide made up of 12 amino acids that include arginine, leucine, lysine, phenylalanine, tryptophan and valine. The “175” is simply a catalog number used by ingredient suppliers to distinguish it from other peptides. Interest in short-chain peptides for skin care took off in the early 2000s when researchers discovered that certain sequences could signal the skin to look and act younger. This ingredient was developed through solid-phase peptide synthesis, a step-by-step process in which amino acids are joined in a specific order, then purified to cosmetic-grade standards.
Because it is synthetic, Oligopeptide-175 is free from animal or plant contaminants, making it a good choice for vegan or hypoallergenic formulas. You will most often spot it in lightweight serums, anti aging creams, sheet masks, eye treatments and daily moisturizers that target firmness and smoothness.
Oligopeptide-175’s Cosmetic Benefits/Uses
Oligopeptide-175 functions as a skin-conditioning agent. In a formula it helps the skin feel softer, look more supple and maintain a healthy moisture balance. By supporting the skin’s surface, it can also improve the overall texture of a product, allowing creams or serums to glide on smoothly and absorb evenly.
Who Can Use Oligopeptide-175
Oligopeptide-175 is generally well tolerated by all skin types including dry, oily, combination and sensitive skin thanks to its lightweight texture and low likelihood of clogging pores or triggering excess oil. Its synthetic origin means it is free of animal by-products, making it suitable for vegans and vegetarians who wish to avoid ingredients sourced from animals or animal derivatives.
Current research shows no specific concerns for pregnant or breastfeeding women when the peptide is used topically in standard cosmetic concentrations. That said this is not medical advice and anyone who is pregnant or nursing should check with a healthcare professional before adding new skincare products to their routine just to be safe.
Oligopeptide-175 does not make the skin more sensitive to sunlight so it is not considered a photosensitizer. It can be used both morning and night and pairs well with common actives like niacinamide, hyaluronic acid and non-acidic forms of vitamin C.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical application of Oligopeptide-175 can vary from person to person. The following is a list of potential side effects that could occur even though most users will not experience them when the ingredient is formulated and used correctly.
- Mild redness or stinging usually transient and limited to very sensitive skin
- Localized itching often linked to overuse or applying on compromised skin barriers
- Contact dermatitis rare but possible in individuals with peptide or preservative sensitivities
- Eye irritation if the product accidentally migrates into the eyes
If any of these reactions occur discontinue use and consult a healthcare professional if symptoms persist or worsen.
Comedogenic Rating
Rating: 0/5
Oligopeptide-175 is water soluble and used at very low concentrations so it does not leave an oily or occlusive film that can block pores. Its small molecular size allows it to sit lightly on the skin then rinse or absorb away without trapping sebum or debris. For these reasons it earns a comedogenic rating of 0 out of 5.
This makes it suitable for people who are prone to acne or breakouts.
Keep in mind that the final feel of any product also depends on the other ingredients in the formula. If the peptide is blended into a very rich balm or heavy cream the overall product could still be pore clogging even though the peptide itself is not.
Summary
Oligopeptide-175 is a lab crafted 12-amino-acid peptide that conditions the skin by supporting a smoother surface and a balanced moisture level. It does this by reinforcing the outer layer so water loss is reduced and the skin feels softer and more supple after application.
While peptides like Matrixyl or copper peptides grab most of the headlines, Oligopeptide-175 is quietly becoming more common in serums, eye creams and sheet masks aimed at boosting softness and firmness without heaviness.
Overall safety is high, with very few reports of irritation or allergic response when used at normal cosmetic levels. As with trying any new skincare product it is smart to do a quick patch test first to make sure your skin agrees with the formula.