What Is Oligopeptide-182 D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide?
Oligopeptide-182 D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide is a lab made peptide blend created by linking short chains of amino acids, including D-tryptophan, D-phenylalanine and lysine, then capping the end of the chain with an amide group to boost stability. Because it is synthetic, the ingredient is not harvested from plants or animals but is built through controlled chemical reactions called solid phase peptide synthesis. In this process each amino acid is added to the chain in a set order, then purified to remove leftover reagents and by-products.
Peptide technology has grown since the late 1980s when researchers discovered that small chains of amino acids could signal skin cells to behave in more youthful ways. Companies soon began designing specialty peptides that target specific skin concerns such as uneven tone or loss of firmness. Oligopeptide-182 D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide was developed to offer both brightening and conditioning action in one molecule, making it attractive for formulators looking to simplify ingredient lists.
You will most often spot this peptide in brightening serums, spot correctors, anti-aging creams, sheet masks and lightweight moisturizers aimed at improving overall clarity and smoothness. It is usually included at low concentrations, paired with soothing agents and antioxidants to round out a gentle yet effective formula.
Oligopeptide-182 D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide’s Cosmetic Benefits/Uses
This ingredient brings two key actions to skin care formulas
- Bleaching – helps reduce the look of dark spots and uneven pigmentation by slowing the formation of excess melanin, leading to a more even skin tone and brighter complexion
- Skin conditioning – supports a soft smooth feel by helping the skin hold moisture, improving texture and leaving a conditioned finish
Who Can Use Oligopeptide-182 D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide
This peptide is generally well tolerated by all skin types including dry, oily, combination, normal and even most sensitive skins because it is non acidic and has a neutral pH. Those with a known sensitivity to peptide ingredients or who experience breakouts from rich creams should review the full formula to be sure the product texture and other additives suit their needs.
The molecule is produced entirely in a lab with no animal derived raw materials so it is considered suitable for both vegans and vegetarians provided the finished product has not been tested on animals.
Current data suggests topical peptides have very low systemic absorption and no hormonal activity so formulas containing this ingredient are unlikely to pose a risk during pregnancy or while breastfeeding. That said there is limited research on use in these specific groups and this information is not medical advice. Pregnant or nursing individuals should always discuss any new skincare product with a qualified healthcare provider before adding it to their routine.
Oligopeptide-182 D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide is not known to increase photosensitivity. Even so anyone working to fade dark spots should apply a broad-spectrum sunscreen daily to protect results and prevent new discoloration.
Potential Side Effects/Adverse Reactions
Reactions to topical Oligopeptide-182 D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide vary from person to person. The points below list potential side effects which remain uncommon when the ingredient is used at appropriate levels in a well formulated product.
Mild redness or irritation
Transient itching or tingling at the application site
Dryness or tightness if layered with multiple exfoliating acids or retinoids
Allergic contact dermatitis in individuals sensitive to specific amino acid sequences
Should any uncomfortable reaction occur discontinue use immediately and consult a healthcare professional if symptoms persist or worsen.
Comedogenic Rating
Rating: 0/5
This peptide is water soluble, used at very low levels and leaves no oily or waxy residue that could block pores, so it sits at the bottom of the comedogenic scale. That makes it a solid option for people who deal with clogged pores or frequent breakouts.
Because the molecule is small and does not rely on heavy carriers or occlusive films to stay on the skin, it is unlikely to add to surface congestion in multi step routines.
Summary
Oligopeptide-182 D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide works mainly as a brightener and a skin conditioner. It helps even out tone by slowing extra pigment production while the peptide chain supports a smoother, more hydrated feel. Both actions come from its ability to signal skin cells in a targeted way without harsh exfoliation.
You will not find this peptide in every beauty aisle yet, as it is still considered a specialty ingredient most common in mid to high end brightening serums or spot correctors. Formulators like it because it can replace several single function additives, keeping formulas lighter and simpler.
Available research shows it to be very safe with low irritation risk for most skin types. As with any new product, doing a quick patch test is smart so you can be sure your skin agrees with the full formula.