Oligopeptide-24: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Oligopeptide-24?

Oligopeptide-24 is a lab made chain of 13 amino acids that include arginine, aspartic acid, cysteine, isoleucine, glutamic acid, glycine, methionine and tyrosine. Scientists first explored small peptides like this one in the early 2000s while searching for gentler options to support skin renewal. Its success in test formulas led to quick adoption in premium skin care lines. To create it, chemists use solid phase peptide synthesis, a step by step method that links each amino acid in a precise order, then purify the finished peptide to remove any leftover reactants. You will most often see Oligopeptide-24 in wrinkle fighting serums, eye creams, sheet masks, concentrated ampoules and daily moisturizers aimed at tired or uneven skin.

Oligopeptide-24’s Cosmetic Benefits/Uses

In formulas Oligopeptide-24 works mainly as a skin conditioning agent. It helps skin feel smoother and look more even by supporting its natural repair signals. With regular use products containing this peptide can soften the look of fine lines, improve visible firmness and give the surface a refreshed glow.

Who Can Use Oligopeptide-24

Because Oligopeptide-24 is lightweight and water soluble it blends well into most textures, making it generally suitable for dry, normal, combination, oily and sensitive skin. It does not add extra oil or clog pores so acne prone users typically tolerate it. Those with extremely reactive or allergy prone skin should watch for redness or itching when trying any new peptide formula, but there are no known skin type restrictions unique to this ingredient.

The peptide is made entirely by chemical synthesis without animal derived raw materials, so products featuring Oligopeptide-24 are usually considered vegan and vegetarian friendly. Always double-check the full ingredient list to be sure supporting ingredients and processing aids align with personal ethics.

No data suggests that topical Oligopeptide-24 poses specific risks during pregnancy or while breastfeeding. However this is not medical advice and anyone who is pregnant or nursing should review all skincare choices with a qualified healthcare professional before use.

Oligopeptide-24 does not increase photosensitivity, meaning it will not make skin more prone to sunburn. Daily sunscreen is still recommended for overall skin health but there is no extra UV caution tied to this peptide.

Potential Side Effects/Adverse Reactions

Responses to topical Oligopeptide-24 vary from person to person. The effects listed below are possible but uncommon when the ingredient is used correctly by reputable manufacturers and most people experience none of them.

  • Mild redness or warmth some users may notice temporary flushing as the product begins to work
  • Itching or tingling a brief prickly sensation can occur especially on very sensitive skin
  • Dry patches rarely a formula containing this peptide may feel too light for very dry skin leading to flakiness
  • Breakouts though the peptide itself is non comedogenic accompanying rich oils or silicones in a formula may trigger pimples in breakout prone skin
  • Allergic contact dermatitis extremely uncommon but possible if an individual is sensitive to a preservative fragrance or the peptide sequence itself

Discontinue use and consult a healthcare professional if irritation or any adverse reaction occurs

Comedogenic Rating

Rating: 0/5 Oligopeptide-24 is a small water-soluble peptide with no oily or waxy residues so it does not block pores on its own. It lacks heavy carriers like butters or thick silicones that often raise comedogenicity scores. This makes it a safe pick for acne-prone or congestion-prone skin. If breakouts occur they are more likely linked to other ingredients in the same formula rather than the peptide itself. Nothing else about its chemistry suggests a hidden risk of pore clogging.

Summary

Oligopeptide-24 works as a skin-conditioning agent that supports the skin’s natural renewal signals helping to soften fine lines boost visible firmness and even out tone. By delivering a short chain of amino acids it gives skin the building blocks it needs to look smoother and more refreshed. While not as famous as peptides like Matrixyl it is quietly gaining traction in mid to high-end serums eye creams and masks thanks to its gentle efficacy and vegan sourcing.

Current research and user feedback point to a high safety profile with low risk of irritation or pore clogging for most skin types. As with any new skincare ingredient it is wise to perform a small patch test before full use to confirm personal tolerance.

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