What Is Oligopeptide-28?
Oligopeptide-28 is a lab made chain of 12 amino acids that include alanine, arginine, histidine, isoleucine, leucine, lysine, proline and serine. Because it is created in controlled conditions rather than taken from animals or plants, it is considered a synthetic peptide. Peptide research took off in the late 1990s when scientists looked for small protein fragments that could signal the skin to act younger. Oligopeptide-28 emerged from that work and has been added to skincare formulas for more than a decade.
Production starts with combining protected amino acids in a precise order on a solid support. After each link is formed the protective groups are removed, leaving a clean peptide chain. The finished peptide is then purified with filtration and chromatography so it meets cosmetic grade standards.
Brands usually add Oligopeptide-28 to anti aging serums, firming creams, sheet masks, eye treatments, post procedure soothing gels and day or night moisturizers where extra skin support is wanted.
Oligopeptide-28’s Cosmetic Benefits/Uses
In skincare formulas Oligopeptide-28 offers several helpful roles
- Antioxidant: Helps neutralize free radicals formed by UV light or pollution which can slow the look of premature aging and support a brighter, more even tone
- Binding: Acts as a humectant like magnet for water so the formula stays smooth and the skin feels hydrated after application
- Chelating: Grabs stray metal ions in the product that could break down active ingredients which keeps the overall formula stable and extends shelf life
- Skin Protecting: Forms a light protective film on the surface that reduces moisture loss and comforts skin exposed to environmental stress
Who Can Use Oligopeptide-28
Most skin types, including dry, oily and combination skin, can use products that contain Oligopeptide-28. Its light texture and water-binding ability give hydration without a greasy feel, which makes it friendly for acne-prone skin as well. Sensitive skin usually tolerates it because it is a small, highly purified molecule, though individual reactions are always possible.
Since Oligopeptide-28 is made completely in a lab and is not sourced from animals it is suitable for vegans and vegetarians.
No published data links Oligopeptide-28 to problems during pregnancy or while breastfeeding. Still, this is not medical advice and anyone who is pregnant or nursing should check with a doctor before adding new skincare to their routine.
The peptide does not make skin more prone to sunburn so it is not considered photosensitizing. Normal daytime sun protection habits are still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Reactions to topical Oligopeptide-28 differ from person to person. The points below list potential side effects that could occur, though most users will not have these issues when the ingredient has been properly formulated and applied.
- Mild redness or warmth shortly after application
- Itchiness or slight stinging in very sensitive skin
- Rare allergic rash for those who are reactive to peptides
- Temporary tight feeling if layered with strong exfoliating acids
If any of these effects show up and do not calm down quickly stop using the product and seek advice from a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0 / 5
Oligopeptide-28 is a small, water-soluble molecule that does not contain heavy oils or waxes that typically block pores. It is used in very low concentrations, sits lightly on the skin and rinses away easily, so it earns a non-comedogenic score of 0. This means it is generally suitable for acne-prone or breakout-prone skin types.
Because the peptide can help bind water and reinforce the skin surface, it may even support a balanced barrier, which can indirectly reduce congestion for some users.
Summary
Oligopeptide-28 functions as an antioxidant, binder, chelating agent and skin protectant. It scavenges free radicals, attracts and holds moisture, captures metal ions that could destabilize a formula and forms a light film that shields the skin from moisture loss and environmental stress.
While not as famous as buzzier peptides like Matrixyl or copper peptides, Oligopeptide-28 has carved out a steady niche in targeted serums, eye creams and post-procedure products because of its versatility and gentle profile.
Current research and decades of cosmetic use show it to be a safe ingredient with a very low risk of irritation or comedogenicity. Still, skin can be unpredictable so it is always smart to patch test a new product before applying it to the entire face.