Oligopeptide-46: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Oligopeptide-46?

Oligopeptide-46 is a lab-made chain of 50 amino acids built from familiar building blocks like alanine, glycine, serine and lysine. Because it is synthetic, chemists can control its purity and performance better than naturally sourced peptides. The idea of adding peptides to skin care took off in the late 1990s when researchers learned these small proteins could signal skin cells to behave in a more youthful way. Oligopeptide-46 is one of the newer options created to fine-tune those signals and improve skin feel.

The peptide is produced through solid-phase peptide synthesis, a step-by-step method where each amino acid is added in a set order on a resin bead. Once all 50 amino acids are in place the chain is clipped from the bead, purified with filters and gentle solvents then dried into a fine powder. This powder is later dissolved into water-based solutions or creams by cosmetic chemists.

You will usually find Oligopeptide-46 in anti aging serums, firming creams, sheet masks, eye gels and advanced moisturizers. Brands choose it when they want to boost skin softness and overall conditioned feel without turning to oils or heavy butters.

Oligopeptide-46’s Cosmetic Benefits/Uses

Oligopeptide-46 is classed as a skin conditioning agent, meaning its main job is to support a smooth, soft and healthy skin surface. When blended into a formula the peptide can help skin hold moisture better, improve the feel of rough patches and give a more refined look over time.

Who Can Use Oligopeptide-46

Because Oligopeptide-46 is lightweight and water soluble it suits most skin types, including dry, normal, combination and oily skin. Sensitive skin usually tolerates it well since the peptide is non acidic and free of fragrance, though anyone with a history of peptide allergies should stay cautious.

The ingredient is produced entirely by synthetic methods with no animal derived material so it is considered suitable for both vegans and vegetarians.

Current research shows no specific risks for pregnant or breastfeeding women when Oligopeptide-46 is used in topical products. This is not medical advice and anyone who is pregnant or nursing should ask a doctor before adding new skincare, just to be safe.

The peptide does not absorb UV light or make skin more reactive to the sun so it is not linked to photosensitivity. Normal daily sunscreen habits remain enough.

Potential Side Effects/Adverse Reactions

Side effects from topical Oligopeptide-46 can vary person to person. The points below list potential reactions but they are unlikely for most users when the product is well formulated.

  • Mild redness or warmth at the application site
  • Itching or tingling shortly after application
  • Dry patches if used in a very high concentration without supporting moisturizers
  • Rare allergic contact dermatitis in individuals sensitive to specific amino acid sequences
  • Breakouts in acne-prone skin if the overall formula contains pore-clogging ingredients not related to the peptide

If you notice any of these effects stop using the product and consult a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 0 out of 5. Oligopeptide-46 is a large, water-soluble molecule that does not contain heavy oils, waxes or fatty acids known to block pores. Its size limits penetration into the follicle so it mainly stays on the skin surface where it conditions rather than congests. This makes it suitable for people prone to acne or breakouts. Because the peptide is usually delivered in lightweight serums or gels, the surrounding formula is also unlikely to be greasy, further keeping the risk of clogged pores low.

Summary

Oligopeptide-46 is a lab crafted 50-amino-acid peptide used for skin conditioning. It helps the skin hold moisture, encourages a smoother texture and can give a subtly firmer look over time by acting as a gentle cell communicator. While it is effective, it is still a niche ingredient seen mainly in premium anti aging serums and eye treatments rather than everyday moisturizers.

Safety profiles are favorable: it is non-comedogenic, vegan friendly and generally well tolerated by all skin types with few reported side effects. As with any new skincare ingredient it is smart to perform a quick patch test the first time you try a product containing Oligopeptide-46, just to be sure your skin agrees with it.

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