What Is Oligopeptide-73?
Oligopeptide-73 is a lab-made chain of 11 amino acids that include arginine, aspartic acid, cysteine, glutamine, glycine, isoleucine, leucine, serine and tyrosine. Peptides like this are short fragments of proteins that can signal the skin to behave in certain helpful ways. Scientists first explored small peptides for cosmetic use in the early 2000s when they noticed some could smooth fine lines and improve skin feel. Oligopeptide-73 was developed during that wave of research and earned a spot in formulas aimed at keeping skin comfortable and healthy.
To create Oligopeptide-73, chemists use solid-phase peptide synthesis, a step-by-step process that links amino acids in a precise order. The finished peptide is then purified, dried and added to a water-friendly carrier so it blends smoothly into creams and serums.
You will usually find Oligopeptide-73 in moisturizers, anti-aging serums, sheet masks, eye creams and leave-on lotions that promise extra softness or resilience.
Oligopeptide-73’s Cosmetic Benefits/Uses
In skin care formulas Oligopeptide-73 mainly acts as a skin-conditioning agent. By supporting the surface of the skin it can help products leave a smoother, softer finish and improve overall comfort during wear.
Who Can Use Oligopeptide-73
Oligopeptide-73 is generally considered suitable for all major skin types including oily, dry, combination and sensitive skin because it is lightweight, water-soluble and non-occlusive. Those with very reactive or compromised skin may still prefer a minimal ingredient list to avoid cumulative irritation from other formula components, not the peptide itself.
The peptide is produced entirely through laboratory synthesis so it contains no animal-derived materials, making it appropriate for vegans and vegetarians.
Current research shows no specific issues for women who are pregnant or breastfeeding when Oligopeptide-73 is used topically at typical cosmetic levels. This is not medical advice and anyone who is expecting or nursing should consult a healthcare professional before introducing new skincare products.
Oligopeptide-73 does not increase photosensitivity, so it does not make skin more prone to sunburn. Normal daily sunscreen use is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Reactions to topical Oligopeptide-73 vary from person to person. The following points outline potential side effects but most users will not experience them when the ingredient is included in a well-formulated product.
- Temporary redness or warmth at the application site
- Mild stinging or tingling on very sensitive skin
- Rare allergic contact dermatitis if an individual is allergic to one of the peptide’s amino acid residues
- Interaction with other actives that alters skin pH, leading to minor dryness or tightness
If any concerning reaction occurs discontinue use and seek advice from a healthcare professional
Comedogenic Rating
Rating: 0/5. Oligopeptide-73 is a small, water-soluble molecule that does not create an oily film or clog pores, so it earns a non-comedogenic score. Its light texture makes it unlikely to trap dead skin cells or sebum, which are the main triggers for breakouts. This means the ingredient is generally suitable for people prone to acne or congestion. As with any product, the overall formula matters more than a single component, so heavier oils, waxes or silicones paired with the peptide could still cause issues if your skin is very clog-prone.
Summary
Oligopeptide-73 is a lab-crafted 11-amino-acid peptide used mainly for skin conditioning. By sitting on the skin’s surface it helps products feel smoother and more comfortable while signaling the skin to maintain a healthy barrier. Although it is effective, the peptide is still a niche choice and you will not see it featured as prominently as buzzier actives like hyaluronic acid or retinol.
Current data shows the ingredient is low risk for irritation, suitable for all skin types and non-comedogenic, so most users can enjoy it without concern. Still, every complexion is unique, so do a quick patch test when trying any new product that contains Oligopeptide-73 just to be sure your skin agrees with it.