What Is Oligopeptide-78?
Oligopeptide-78 is a lab-made chain of 11 amino acids: alanine, glutamine, glycine, isoleucine, lysine, proline and valine. Peptide researchers designed it to mimic small fragments of the skin’s own proteins, giving it good compatibility with topical products. First explored in the early 2000s, it gained attention when formulators looked for gentle alternatives to heavy oils for improving skin feel. Today it is produced through solid-phase peptide synthesis, a step-by-step process that links protected amino acids in a specific order then removes the protecting groups and purifies the finished peptide. Because the sequence is consistent every time, the quality and potency remain predictable.
You will most often spot Oligopeptide-78 in lightweight serums, anti-aging creams, sheet masks and overnight moisturizers. Brands add it to support smoother texture without leaving a greasy after-feel, making it popular in both premium and mass-market ranges.
Oligopeptide-78’s Cosmetic Benefits/Uses
In skincare formulas Oligopeptide-78 acts as a skin-conditioning agent. By sitting on the surface and lightly binding moisture it helps the complexion feel softer and look more even, which can enhance the overall sensory experience of a product.
Who Can Use Oligopeptide-78
Thanks to its lightweight, moisture-binding nature Oligopeptide-78 is generally suitable for all skin types including dry, normal, combination, oily and sensitive. It does not clog pores or leave a heavy residue so acne-prone users usually tolerate it well. There are no known skin types that should strictly avoid it, though anyone with a confirmed allergy to peptides or any other formula component should steer clear.
The peptide is made synthetically without ingredients of animal origin which makes it appropriate for vegans and vegetarians.
No specific data links Oligopeptide-78 to problems during pregnancy or while nursing. That said this information is educational only and not medical advice; expecting or breastfeeding users should consult a healthcare professional before adding any new skincare product.
Oligopeptide-78 does not increase photosensitivity so routine daytime use should not raise the risk of sunburn. Standard sun protection practices should still be followed.
Potential Side Effects/Adverse Reactions
Side effects from topical Oligopeptide-78 can vary from person to person. The points below outline potential reactions, but they are uncommon when the ingredient is formulated and used correctly.
- Transient redness or flushing
- Mild itching or tingling
- Localized irritation in sensitive individuals
- Rare allergic contact dermatitis
- Breakouts if combined with comedogenic ingredients in the same product
If any of these issues appear discontinue use and seek advice from a qualified healthcare provider or dermatologist.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Oligopeptide-78 is water soluble, used at very low concentrations and lacks the heavy oils or waxes that typically block pores. Its small peptide structure sits lightly on the surface then absorbs, so it is highly unlikely to trap sebum or debris in follicles. For these reasons it earns a 0 out of 5.
This makes it suitable for acne-prone or breakout-prone skin. The only caveat is that the final product’s overall formula matters; if the peptide is blended into a rich base that contains pore-clogging oils the finished product could still trigger blemishes even though the peptide itself will not.
Summary
Oligopeptide-78 is a lab-crafted 11-amino-acid peptide used mainly as a skin-conditioning agent. By lightly binding water and mimicking fragments of natural skin proteins it helps the surface feel softer and look smoother. It shows up most often in modern serums, masks and lightweight creams, especially in lines that focus on a fresh non-greasy skin feel, though it is still a niche ingredient compared with better known peptides.
Current safety data indicate low irritation risk, no pore-clogging tendency and no links to increased photosensitivity, making it a generally safe addition to daily routines. As with any new skincare ingredient it is wise to patch test a product containing Oligopeptide-78 before full-face use, just to ensure personal compatibility.